SUMMARY:
Panitumumab (Vectibix), is a human monoclonal antibody EGFR antagonist indicated as a single agent for the treatment of metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine, oxaliplatin, and irinotecan chemotherapy regimens. This article will present the mechanism of action as well as the clinical role for this monoclonal antibody.
Abbreviations
- c-erbB-1
- EGFR gene
- EGFR
- epidermal growth factor receptor
- FDA
- US Food and Drug Administration
- HER
- human epidermal growth factor receptor
- KRAS
- Kristen rat sarcoma viral oncogene homolog
- Copyright © American Society of Neuroradiology