Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleHEAD & NECK

Imaging Appearance of SMARCB1 (INI1)-Deficient Sinonasal Carcinoma: A Newly Described Sinonasal Malignancy

D.R. Shatzkes, L.E. Ginsberg, M. Wong, A.H. Aiken, B.F. Branstetter, M.A. Michel and N. Aygun
American Journal of Neuroradiology October 2016, 37 (10) 1925-1929; DOI: https://doi.org/10.3174/ajnr.A4841
D.R. Shatzkes
aFrom the Department of Radiology (D.R.S., M.W.), Lenox Hill Hospital, Northwell Health, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.R. Shatzkes
L.E. Ginsberg
bDepartment of Radiology (L.E.G.), The University of Texas MD Anderson Cancer Center, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L.E. Ginsberg
M. Wong
aFrom the Department of Radiology (D.R.S., M.W.), Lenox Hill Hospital, Northwell Health, New York, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Wong
A.H. Aiken
cDepartment of Radiology (A.H.A.), Neuroradiology Division, Emory University Hospital, Atlanta, Georgia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.H. Aiken
B.F. Branstetter IV
dDepartment of Radiology (B.F.B.), Presbyterian Hospital, Pittsburgh, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.F. Branstetter IV
M.A. Michel
eDepartment of Radiology (M.A.M.), Medical College of Wisconsin, Milwaukee, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.A. Michel
N. Aygun
fDepartment of Radiology (N.A.), Johns Hopkins Medicine, Baltimore, Maryland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Aygun
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References
  • PDF
Loading

Abstract

SUMMARY: SMARCB1 (INI1)-deficient sinonasal carcinomas were first described in 2014, and this series of 17 cases represents the first imaging description. This tumor is part of a larger group of SMARCB1-deficient neoplasms, characterized by aggressive behavior and a rhabdoid cytopathologic appearance, that affect multiple anatomic sites. Clinical and imaging features overlap considerably with other aggressive sinonasal malignancies such as sinonasal undifferentiated carcinoma, which represents a common initial pathologic diagnosis in this entity. SMARCB1 (INI1)-deficient sinonasal tumors occurred most frequently in the nasoethmoidal region with invasion of the adjacent orbit and anterior cranial fossa. Avid contrast enhancement, intermediate to low T2 signal, and FDG avidity were frequent imaging features. Approximately half of the lesions demonstrated calcification, some with an unusual “hair on end” appearance, suggesting aggressive periosteal reaction.

Malignancy of the sinonasal cavity is characterized by considerably greater heterogeneity than malignancy of the upper aerodigestive tract, where squamous cell carcinoma predominates. Though squamous cell carcinoma remains the most common sinonasal malignancy (approximately 60% of cases), there is a diverse and growing array of additional histologies, including tumors of epithelial, neuroectodermal, lymphoproliferatve, and mesenchymal origins.1⇓⇓–4 Though imaging features of the various histologies overlap considerably, some tumors demonstrate characteristic findings that support a particular diagnosis, such as T1 shortening in melanoma or chondroid calcification in chondrosarcoma. Other tumors might demonstrate findings that, though not specific to a single diagnosis, suggest their aggressive nature. Ultimately, tissue sampling is necessary to confirm pathologic diagnosis before treatment planning. Nevertheless, most sinonasal masses present with very nonspecific clinical findings indistinguishable from rhinosinusitis, and the ability of the radiologist to suggest an underlying malignancy is useful in directing short-term management, including the need for further imaging and tissue sampling.3⇓⇓⇓⇓–8

SMARCB1 (INI1) is a tumor-suppressor gene that has been implicated in a growing number of malignancies involving multiple anatomic sites, including the kidneys, soft tissues, and CNS.1,2,9⇓–11 The first reports of SMARCB1 (INI1)-deficient tumors of the sinonasal cavity appeared in the pathology literature in 2014,1,9 followed by an additional small case series in 2015.2 To our knowledge, there have been 16 cases reported in the world literature. However, the imaging appearance of SMARCB1 (INI1)-deficient sinonasal tumors has not yet been described. By analyzing a case series of 17 patients collected from 6 different centers, some of whom were included in the pathologic reports listed above, we aimed to provide a comprehensive description of the appearance of these tumors on CT, MR imaging, and PET/CT studies. We also hoped to increase awareness of this relatively new entity among both radiologists and clinicians to facilitate its diagnosis when encountered in clinical practice.

Materials and Methods

This retrospective case series was performed with institutional review board approval and exemption from informed consent following the guidelines of the Health Insurance Portability and Accountability Act. Records of cases presented at our multidisciplinary tumor board since 2014 were reviewed for the pathologic diagnosis of SMARCB1 (INI1)-deficient sinonasal tumors. In addition, cases were solicited from head and neck radiologists at other medical centers. In all, 17 cases were collected from 6 centers, 10 of which were included in prior case series.2,9 In most cases, the diagnosis of SMARCB1 (INI1)-deficient carcinoma represented an amendment of an initial alternate diagnosis. Patient demographics, original pathologic diagnoses, cancer stage, current clinical status, and publication history (where applicable) are summarized in the Table.

View this table:
  • View inline
  • View popup

Patient demographics

All available pretreatment CT, MR imaging, and/or PET/CT studies were reviewed on a PACS or DICOM viewer by a single radiologist with over 20 years of experience in head and neck imaging. MR and PET/CT imaging were available in 14 and 11 patients, respectively. CT images, either as a stand-alone examination or as part of a PET/CT examination, were available in 13 patients. Tumor characteristics compiled were specific location within the sinonasal cavity; the presence of any intracranial, orbital, or perineural extension; and the presence of regional nodal or distant metastases. Imaging parameters included CT attenuation, enhancement, and calcification patterns; MR signal characteristics and enhancement pattern; and the predominant pattern of osseous change. Osseous change was characterized as expansion, erosion, or a combination of both by review of both CT and MR images. PET/CT studies were reviewed for tumor FDG avidity and for the presence of regional nodal or distant metastases. Standard uptake values were unavailable for most of the imaging studies and were not recorded. Similarly, CT and MR imaging technical parameters were not recorded because most imaging was performed at facilities outside of the tertiary centers where the patients were referred for treatment.

Results

Patient Characteristics

Patient characteristics are summarized in the Table. There were 10 men and 7 women, with an average age of 54 years (range, 33–78 years; median 51 years). The initial pathologic diagnoses were sinonasal undifferentiated carcinoma in 5 patients, poorly differentiated carcinoma (squamous, basaloid, adeno, or not otherwise specified) in 6, myoepithelial carcinoma in 2, high-grade mixed germ cell tumor in 1, and SMARCB1 (INI1) sinonasal carcinoma in 1. All but 1 patient presented with T4 disease (n = 15, T-stage was not available for 2 patients). There were no regional nodal metastases detected in the 12 patients for whom preoperative PET/CT was available. A contralateral mandibular lesion in patient 17 represented the only distant metastasis identified in this subgroup of 12 patients. All patients underwent surgery and variable chemoradiation regimens, and 10 patients were alive without evidence of disease at last available follow-up (average follow-up interval, 14.6 months; range, 1–48 months; median, 11 months). In patient 3, with a follow-up interval of 48 months, the initial pathology was reviewed at the time of suspected recurrence and the diagnosis amended from poorly differentiated adenocarcinoma to SMARCB1 (INI1)-deficient carcinoma. To date, 4 patients with recurrence are alive and 3 have died.

Tumor Characteristics

Tumor characteristics are summarized in the On-line Table, and representative images are provided in Figs 1 and 2. The most common tumor location was nasoethmoidal (n = 8), followed by nasal (n = 5) and sphenoethmoidal (n = 2), and 1 tumor was centered in the frontoethmoidal region with a large supraorbital component. Another very extensive tumor had components in the nasal cavity and ethmoid, sphenoid, and maxillary sinuses. There was epidural intracranial extension in 8 tumors and intradural extension in 3. Orbital invasion, present in 9 patients, was characterized as extraconal and/or conal in all. In patient 16, a tumor was identified in the cavernous sinus and foramen ovale; this tumor originated in the sphenoethmoidal region, and direct cavernous sinus invasion was suspected. In patient 10, only PET/CT was available and deemed insufficient to accurately assess potential intracranial, intraorbital, or perineural extension. In 2 other patients, imaging was deemed to be of insufficient quality to assess for perineural spread.

Fig 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Fig 1.

Patient 1. A, Coronal enhanced CT image shows moderately enhancing tumor in the nasoethmoidal region eroding the cribriform plate and ethmoid roof, with intracranial extension more conspicuous on the left (dashed arrow). There is also erosion through the right lamina papyracea with contact to the right superior oblique muscle (solid arrow). Bone changes in this case were deemed primarily erosive rather than expansile. B, Coronal enhanced and fat-suppressed T1WI shows avid heterogeneous enhancement in the transcranial mass. C, Coronal T2WI shows mild T2 hyperintensity of the transcranial mass compared with the cerebral cortex. Though there is signal abnormality in the left frontal lobe, no intradural disease was identified during surgical resection.

Fig 2.
  • Download figure
  • Open in new tab
  • Download powerpoint
Fig 2.

Patient 2. A, Coronal enhanced and fat-suppressed T1WI shows avid heterogeneous enhancement in right nasal cavity mass. There is no intracranial or orbital extension, and this mass was characterized as expansile. B, On this coronal STIR image, the mass is approximately isointense to cerebral cortex and can be distinguished from obstructive secretions in the adjacent ethmoid and maxillary sinuses. C, Coronal fused image from PET/CT examination demonstrates avid uptake in the right nasal cavity mass.

Precontrast CT images were available in 8 patients, and the tumor was isoattenuated to skeletal muscle in 6. Contrast enhancement of the tumor was identified in all 7 patients for whom both pre- and postcontrast CT images were available. This was graded as moderate in 6 patients and avid in 1 and further characterized as heterogeneous in 6. Calcification was present in 6 of the 13 patients for whom CT imaging was available. In 3 patients, there was a spiculated “hair on end” pattern of calcification along the interface, with adjacent bone suggesting aggressive periosteal reaction (Fig 3). In patient 11, floccular calcification present along the margin of the tumor with the medial orbital wall was deemed to potentially represent a more solid pattern of periosteal reaction. In 2 patients, stippled and curvilinear calcifications were present within the tumor, thought to likely represent retained bone fragments within a background of bone destruction. The impact on adjacent bony structures was assessed on both CT and MR imaging. Bone changes were classified as predominantly erosive in 9 patients, expansile in 5, and a combination of expansile and erosive in 3.

Fig 3.
  • Download figure
  • Open in new tab
  • Download powerpoint
Fig 3.

Calcification. A, Patient 9. Coronal CT bone image demonstrates spiculated, “hair on end” calcification along right medial orbital wall, with permeative lytic change in the adjacent bone (arrows). B, Patient 13. There is a similar pattern of “hair on end” calcification involving the floor of the right frontal sinus on this coronal CT image (arrows). In both patients, the involved bone is demineralized but not destroyed. C, Patient 11. There is a more solid, floccular pattern of calcification along the right medial orbital wall on this axial CT image (arrows).

The tumor was isointense to cortex in 11 of the 14 patients for whom precontrast T1WI was available. In the remaining 3 patients, the tumor was graded as mildly hypointense. The tumor was variably mildly hypointense (n = 4), isointense (n = 4), moderately hyperintense (n = 3), and mildly hyperintense (n = 3) to cortex on T2WI. Enhancement was graded as avid in 11 of the 14 patients for whom postcontrast MR imaging was available, with the remaining tumors demonstrating moderate enhancement. Enhancement was additionally characterized as heterogeneous (n = 7) and homogeneous (n = 7). DWI was available for 9 patients. Most lesions (n = 7) showed moderate diffusion restriction.

FDG uptake was demonstrated in all 12 patients who underwent PET/CT scanning. Radiotracer uptake was graded as avid in 9 patients and moderate in 3.

Discussion

SMARCB1 is a tumor-suppressor gene located on chromosome 22q11.2.1,2,9,10 Deficiency of SMARCB1 (INI1) was first implicated in malignant rhabdoid tumors of infancy, followed by rhabdoid tumor of the CNS, kidney, and soft tissue.1,2,9,10 This list has since grown to include a diverse group of neoplasms in multiple anatomic sites, all of which are characterized by a rhabdoid appearance on cytopathologic examination and generally aggressive behavior.1,2,9,10 The first descriptions of SMARCB1 (INI1)-deficient neoplasms of the sinonasal tract were published simultaneously in the pathology literature by 2 separate groups in September 2014.1,9 A third case series, completing a total of 16 reported cases, was published in September 2015.2 Our series, with an additional 7 cases, represents the fourth report and the first detailed imaging description of this entity.

It is difficult to estimate the prevalence of this disease because most cases were initially diagnosed as other high-grade malignant tumors, most commonly sinonasal undifferentiated carcinoma and other poorly differentiated carcinomas often qualified as having rhabdoid or basaloid features. In their review of their own cases and those previously reported, Bell et al2 found that SMARCB1 (INI1)-deficient sinonasal carcinomas represented 3.3% of a combined series of 484 sinonasal primary tumors. However, Bishop et al9 noted that SMARCB1 (INI1)-deficient sinonasal carcinomas represented 14% of previously diagnosed sinonasal undifferentiated carcinomas.9 More accurate estimates will likely be available once the diagnosis is more widely known in the head and neck oncologic community.

There are few sinonasal tumors with highly characteristic or pathognomonic imaging or clinical features, and this tumor is no exception. With regard to patient demographics, the wide age range and median age of 51 years overlap with virtually all sinonasal malignancies except those found in pediatric age groups, such as juvenile nasopharyngeal angiofibroma and rhabdomyosarcoma. A clear predilection for late-stage presentation was identified in our series, with only 1 patient staged below T4. However, this is the case in most aggressive sinonasal malignancies.6,8,12,13 We found a predilection for central structures, with 13 of 17 tumors described as nasal or nasoethmoidal in origin, with frequent invasion into the adjacent orbital and intracranial compartments. Other sinonasal malignancies such as sinonasal undifferentiated carcinoma, esthesioneuroblastoma, lymphoma, and melanoma arise most frequently in the superior nasal cavity with similar patterns of invasion. The tendency toward avid enhancement, intermediate T2 signal intensity, moderate diffusion restriction, and FDG avidity demonstrated in our series is characteristic for sinonasal undifferentiated carcinoma and squamous cell carcinoma, which, though occurring most commonly in the paranasal sinuses (75%), must still be considered when nasal cavity masses are identified because of the high relative prevalence of this diagnosis.1⇓⇓–4,7,12 CT imaging demonstrated associated calcification in close to half of the tumors (6 of 13), though no tumor calcification was reported on histopathologic analysis. In considering this discrepancy, we felt that calcification might reflect retained bone fragments in 2 patients and an aggressive periosteal reaction in 4. Nevertheless, our observed frequency of calcification on CT exceeds that reported in the literature, and the perpendicular “hair on end” appearance suggesting aggressive periosteal reaction is a particularly unusual feature.5,7,12,14 A more accurate estimation of the incidence of this and other imaging features, and of their potential utility as indicators of this disease, will require a larger sample size.

Limitations

In addition to the small sample size, other substantial limitations are related to the pooling of data from multiple centers. Much of the imaging reviewed was performed outside of these tertiary referral centers, and both imaging protocols and quality varied widely. Technical specifications of scanners and specifics of pulse sequence parameters were generally unavailable and were not compiled. There were similar limitations on the availability of clinical information, and length of follow-up was necessarily limited because of the short interval after initial description of the entity. There are few prospectively acquired data regarding imaging appearance of sinonasal malignancies, and available information is largely limited to relatively small case series such as ours. Therefore, comparisons with other sinonasal malignancies are fraught with similar limitations of small sample size and heterogeneous data.

Conclusions

The recently described entity of SMARCB1 (INI1)-deficient sinonasal carcinoma should be included in the differential diagnosis of a central sinonasal mass demonstrating aggressive imaging features, particularly when there is associated calcification. Overlap in clinical and imaging features of SMARCB1 (INI1)-deficient carcinoma with other sinonasal malignancies, such as sinonasal undifferentiated carcinoma, underscores the challenges currently faced in diagnosis of these entities. The presence of rhabdoid features on cytopathologic examination will help alert pathologists and clinicians to the possibility of this diagnosis so confirmation can be achieved using appropriate testing. As the diagnosis becomes more widely known, we anticipate the opportunity for larger series and more accurate assessment of clinical and imaging features of this disease.

Acknowledgments

The authors gratefully acknowledge contribution of case material from Drs. Justin A. Bishop and John M. DelGaudio.

Footnotes

  • Disclosures: Michelle A. Michel—UNRELATED: Payment for Lectures (including service on speakers bureaus): iiCME, Comments: lectured at a continuing medical education course in January 2016 and received honoraria; Royalties: Elsevier, Comments: received a royalty check for prior contributions to Diagnostic Imaging textbooks; Stock/Stock Options: Fidelity, Transamerica, Comments: personal investments only.

References

  1. 1.↵
    1. Agaimy A,
    2. Koch M,
    3. Lell M, et al
    . SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol 2014;38:1274–81 doi:10.1097/PAS.0000000000000236 pmid:24832165
    CrossRefPubMed
  2. 2.↵
    1. Bell D,
    2. Hanna EY,
    3. Agaimy , et al
    . Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. Virchows Arch 2015;467:649–56 doi:10.1007/s00428-015-1853-1 pmid:26407663
    CrossRefPubMed
  3. 3.↵
    1. Eggesbø HB
    . Imaging of sinonasal tumours. Cancer Imaging 2012;12:136–52 doi:10.1102/1470-7330.2012.0015
    CrossRefPubMed
  4. 4.↵
    1. Sen S,
    2. Chandra A,
    3. Mukhopadhyay S, et al
    . Sinonasal tumors: computed tomography and MR imaging features. Neuroimaging Clin N Am 2015;25:595–618 doi:10.1016/j.nic.2015.07.006 pmid:26476382
    CrossRefPubMed
  5. 5.↵
    1. Loevner LA,
    2. Sonners AI
    . Imaging of neoplasms of the paranasal sinuses. Neuroimaging Clin N Am 2004;14:625–46 doi:10.1016/j.nic.2004.07.005 pmid:15489145
    CrossRefPubMed
  6. 6.↵
    1. Lund VJ,
    2. Stammberger H,
    3. Nicolai P, et al
    . European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol Suppl 2010;22:1–143 pmid:20502772
    PubMed
  7. 7.↵
    1. Phillips CD,
    2. Futterer SF,
    3. Lipper MH, et al
    . Sinonasal undifferentiated carcinoma: CT and MR imaging of an uncommon neoplasm of the nasal cavity. Radiology 1997;202:477–80 doi:10.1148/radiology.202.2.9015077 pmid:9015077
    CrossRefPubMed
  8. 8.↵
    1. Sen S,
    2. Chandra A,
    3. Mukhopadhyay S, et al
    . Imaging approach to sinonasal neoplasms. Neuroimaging Clin N Am 2015;25:577–93 doi:10.1016/j.nic.2015.07.005 pmid:26476381
    CrossRefPubMed
  9. 9.↵
    1. Bishop JA,
    2. Antonescu CR,
    3. Westra WH
    . SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. Am J Surg Pathol 2014;38:1282–89 doi:10.1097/PAS.0000000000000285 pmid:25007146
    CrossRefPubMed
  10. 10.↵
    1. Bishop JA
    . Newly described tumor entities in sinonasal tract pathology. Head Neck Pathol 2016;10:23–31 doi:10.1007/s12105-016-0688-7 pmid:26830406
    CrossRefPubMed
  11. 11.↵
    1. Kalimuthu SN,
    2. Chetty R
    . Gene of the month: SMARCB1. J Clin Pathol 2016;69:484–89 doi:10.1136/jclinpath-2016-203650 pmid:26941181
    Abstract/FREE Full Text
  12. 12.↵
    1. Sivalingam J,
    2. Sarawagi R,
    3. Raghuwanshi S, et al
    . Sinonasal neoplasia: clinicopathological profile and importance of computed tomography. J Clin Diagn Res 2015;9:TC01–4 doi:10.7860/JCDR/2015/13514.6026 pmid:26266182
    CrossRefPubMed
  13. 13.↵
    1. Xu CC,
    2. Dziegielewski PT,
    3. McGaw WT, et al
    . Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. J Otolaryngol Head Neck Surg 2013;42:2 doi:10.1186/1916-0216-42-2 pmid:23663264
    CrossRefPubMed
  14. 14.↵
    1. Rana RS,
    2. Wu JS,
    3. Eisenberg RL
    . Periosteal reaction. AJR Am J Roentgenol 2009;193:W259–72 doi:10.2214/AJR.09.3300 pmid:19770293
    CrossRefPubMed
  • Received March 31, 2016.
  • Accepted after revision April 22, 2016.
  • © 2016 by American Journal of Neuroradiology
View Abstract
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 37 (10)
American Journal of Neuroradiology
Vol. 37, Issue 10
1 Oct 2016
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Imaging Appearance of SMARCB1 (INI1)-Deficient Sinonasal Carcinoma: A Newly Described Sinonasal Malignancy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Imaging Appearance of SMARCB1 (INI1)-Deficient Sinonasal Carcinoma: A Newly Described Sinonasal Malignancy
D.R. Shatzkes, L.E. Ginsberg, M. Wong, A.H. Aiken, B.F. Branstetter, M.A. Michel, N. Aygun
American Journal of Neuroradiology Oct 2016, 37 (10) 1925-1929; DOI: 10.3174/ajnr.A4841

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Imaging Appearance of SMARCB1 (INI1)-Deficient Sinonasal Carcinoma: A Newly Described Sinonasal Malignancy
D.R. Shatzkes, L.E. Ginsberg, M. Wong, A.H. Aiken, B.F. Branstetter, M.A. Michel, N. Aygun
American Journal of Neuroradiology Oct 2016, 37 (10) 1925-1929; DOI: 10.3174/ajnr.A4841
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Imaging Review of New and Emerging Sinonasal Tumors and Tumor-Like Entities from the Fourth Edition of the World Health Organization Classification of Head and Neck Tumors
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • CT and MR Imaging Appearance of the Pedicled Submandibular Gland Flap: A Potential Imaging Pitfall in the Posttreatment Head and Neck
  • Increased Labyrinthine T1 Postgadolinium Signal Intensity Is Associated with the Degree of Ipsilateral Sensorineural Hearing Loss in Patients with Sporadic Vestibular Schwannoma
  • MRI for Cushing Disease: A Systematic Review
Show more HEAD & NECK

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire