Multiparametric Imaging Improves Confidence in the Diagnosis of Multinodular and Vacuolating Neuronal Tumor of the Cerebrum =========================================================================================================================== * A. Lecler * D. Chauvet * H.A. Biassette * J. Savatovsky We read with much interest the article by Nunes et al1 in the July 2017 issue of the *American Journal of Neuroradiology*, in which they presented an impressive series of 33 confirmed or presumed multinodular and vacuolating neuronal tumors (MVNT) of the cerebrum, an entity that has only recently been categorized in the 2016 revision of the *World Health Organization Classification of Tumors of the Central Nervous System*.2⇓–4 Only a few cases of MVNT have been reported in the literature in the past 4 years with confirmed pathologic correlations.1⇓–3 The authors presented a detailed description of the entity, which involves the deep cortical ribbon and the adjacent subcortical white matter and is distributed into small coalescent nodules, hyperintense on FLAIR and T2-weighted imaging and hypointense on T1WI. On our 3T MR imaging, we noticed that these lesions were not homogeneous but had a central FLAIR hyposignal as well as central punctiform T1 hyperintensities (white arrows, Fig 1), probably related to a high protein or solid component within the vacuolated areas. This specific feature was present in all our patients but requires reasonably high resolution to be seen. This simple sign can improve diagnostic confidence. ![Fig 1.](http://www.ajnr.org/https://www.ajnr.org/content/ajnr/39/2/E32/F1.medium.gif) [Fig 1.](http://www.ajnr.org/content/39/2/E32/F1) Fig 1. Axial T1 (*left*) and FLAIR (*right*) weighted imaging showing a right parietal lesion involving the deep cortical ribbon and the adjacent subcortical white matter distributed into small coalescent nodules, hyperintense on FLAIR, hypointense with punctiform hyperintensities on T1WI, and central hypointensities on FLAIR (*arrow*), characteristics of MVNT. We believe that radiologists should always perform multiparametric imaging to characterize brain abnormalities consistent with an MVNT with a high-field MR imaging whenever possible. In our experience, diffusion-weighted imaging shows no restricted diffusion inside the lesion, and susceptibility-weighted imaging does not show an intratumoral susceptibility signal or intralesional hemorrhaging. Perfusion sequences such as dynamic-susceptibility contrast or arterial spin-labeling show no hyperperfusion, increasing neither cerebral blood volume nor cerebral blood flow. MR spectroscopy may show a mild decrease of NAA but no choline peak or lipid or lactate peaks, which might suggest malignancy (Fig 2). Multivoxel MR spectroscopy shows no abnormality in the surrounding brain parenchyma. All these features improve diagnostic confidence and support strong arguments in favor of this presumptive diagnosis, thus avoiding a potentially risky surgical biopsy. ![Fig 2.](http://www.ajnr.org/https://www.ajnr.org/content/ajnr/39/2/E32/F2.medium.gif) [Fig 2.](http://www.ajnr.org/content/39/2/E32/F2) Fig 2. MR spectroscopy shows a mild decrease of *N*-acetylaspartate but no choline or lipids peaks. We think that this systematic approach best serves patients because this entity is provisionally considered a brain tumor by the World Health Organization and should be best understood using state-of-the-art MR imaging characterization. This management allows clinicians to reassure their patients who are often frightened by the term “tumor” and sometimes request surgical removal. In our experience, which is further echoed in the article, long-term follow-up MR imaging performed >10 years after the first discovery of a presumed MVNT shows perfect stability of brain abnormalities with rare or absent clinical symptoms. We entirely agree with the authors' conclusion suggesting that MVNT is more likely a malformative lesion as opposed to a neoplasm. Clinical and histologic analysis have not yet provided clear evidence for a neoplastic process. Molecular investigations in few cases have so far failed to reveal *IDH1/2*, *BRAF* V600E, *EGFR*, *ERBB2*, *KRAS*, *BRAF*, *NRAS*, *PIK3CA*, and *AKT1* mutations or obvious DNA copy number abnormalities. A point mutation involving *MEK1* (*MAP2K1*) p. Q56P (c.167A>C) in non-small-cell lung cancers has been found in 1 case. Thus, we believe that the name of this entity should be changed to remove the term “tumor” and replaced by the term “hamartoma,” “dysplasia,” or “malformation.” We also believe that larger series are needed to determine at what point the entity will be considered malignant. ## Footnotes * Disclosures: Homa A. Biassette—*UNRELATED*: *Grants/Grants Pending*: DEVELAGE FP7 grant,* *Comments*: 2012–2015 “DEVELAGE: Pathways Common to Brain Development and Ageing: Defining Strategies for Preventive Therapy and Diagnostics.” Julien Savatovsky—*UNRELATED*: *Grant*: Association de la Recherche Sur le Syndrome Immuno-Deficitaire Acquis; *Consulting Fee or Honorarium:* Association de la Recherche Sur le Syndrome Immuno-Deficitaire Acquis, Madday Pharmaceutical, Bristol-Myers Squibb, GlaxoSmithKline; *Support for Travel to Meetings for the Study or Other Purposes*: GE Healthcare, Philips Healthcare, Bayer HealthCare; *Expert Testimony:* Philips Healthcare, Bayer HealthCare*; *Payment for Lectures Including Service on Speakers Bureaus*: Philips Healthcare, Association de la Recherche Sur le Syndrome Immuno-Deficitaire Acquis, Biogen.* *Money paid to the institution. ## References 1. 1. Nunes RH, Hsu CC, da Rocha AJ, et al. 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