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Thirty-five thrombus analogs of different compositions were scanned with an MR imaging quantitative T2* mapping sequence. Two radiologists, blinded to thrombus composition, measured the thrombus-T2* relaxation time twice, at an interval of 2 weeks. Quantitative histologic evaluations of red blood cell content were performed. Inter- and intraobserver reproducibility of the thrombus-T2* relaxation time was assessed by calculating intraclass correlation coefficients. MR imaging quantitative T2* mapping can reliably identify the thrombus red blood cell content in vitro. This fast, easy-to-use sequence could be implemented in routine practice.

Sixty-seven patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.

Seventy-seven patients with MS and 44 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, diffusion tensor imaging, perfusion weighted imaging, and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures. In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures.

Thirty-five thrombus analogs of different compositions were scanned with an MR imaging quantitative T2* mapping sequence. Two radiologists, blinded to thrombus composition, measured the thrombus-T2* relaxation time twice, at an interval of 2 weeks. Quantitative histologic evaluations of red blood cell content were performed. Inter- and intraobserver reproducibility of the thrombus-T2* relaxation time was assessed by calculating intraclass correlation coefficients. MR imaging quantitative T2* mapping can reliably identify the thrombus red blood cell content in vitro. This fast, easy-to-use sequence could be implemented in routine practice.

Thirty-five thrombus analogs of different compositions were scanned with an MR imaging quantitative T2* mapping sequence. Two radiologists, blinded to thrombus composition, measured the thrombus-T2* relaxation time twice, at an interval of 2 weeks. Quantitative histologic evaluations of red blood cell content were performed. Inter- and intraobserver reproducibility of the thrombus-T2* relaxation time was assessed by calculating intraclass correlation coefficients. MR imaging quantitative T2* mapping can reliably identify the thrombus red blood cell content in vitro. This fast, easy-to-use sequence could be implemented in routine practice.

Seventy-seven patients with MS and 44 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, diffusion tensor imaging, perfusion weighted imaging, and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures. In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures.

Thirty-five patients with steno-occlusive disease (Moyamoya disease [n = 24], Moyamoya syndrome [n = 3], atherosclerosis [n = 6], vasculitis [n = 1], and idiopathic stenosis [n = 1]) who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass were evaluated. WM cerebrovascular reactivity was measured preoperatively and postoperatively using BOLD MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide. WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-MCA bypass in the revascularized hemisphere in the MCA territory and in the anterior cerebral artery territory.

Thirty-five patients with steno-occlusive disease (Moyamoya disease [n = 24], Moyamoya syndrome [n = 3], atherosclerosis [n = 6], vasculitis [n = 1], and idiopathic stenosis [n = 1]) who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass were evaluated. WM cerebrovascular reactivity was measured preoperatively and postoperatively using BOLD MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide. WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-MCA bypass in the revascularized hemisphere in the MCA territory and in the anterior cerebral artery territory.

Sixty-seven patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.

Thirty-five patients with steno-occlusive disease (Moyamoya disease [n = 24], Moyamoya syndrome [n = 3], atherosclerosis [n = 6], vasculitis [n = 1], and idiopathic stenosis [n = 1]) who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass were evaluated. WM cerebrovascular reactivity was measured preoperatively and postoperatively using BOLD MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide. WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-MCA bypass in the revascularized hemisphere in the MCA territory and in the anterior cerebral artery territory.

Thirty-five thrombus analogs of different compositions were scanned with an MR imaging quantitative T2* mapping sequence. Two radiologists, blinded to thrombus composition, measured the thrombus-T2* relaxation time twice, at an interval of 2 weeks. Quantitative histologic evaluations of red blood cell content were performed. Inter- and intraobserver reproducibility of the thrombus-T2* relaxation time was assessed by calculating intraclass correlation coefficients. MR imaging quantitative T2* mapping can reliably identify the thrombus red blood cell content in vitro. This fast, easy-to-use sequence could be implemented in routine practice.

Seventy-seven patients with MS and 44 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, diffusion tensor imaging, perfusion weighted imaging, and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures. In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures.

Sixty-seven patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.

Two characteristics of the susceptibility vessel sign, overestimation ratio (overR), a quantitative evaluation of the susceptibility vessel sign, and the 2-layered susceptibility vessel sign (TL-SVS), were reported to predict cardioembolic stroke. These 2 biomarkers, on 1.5T or 3T systems (159 and 101 patients, respectively), demonstrated high specificity (0.77 at 1.5T and 1 at 3T) and their simultaneous presence is highly associated with cardioembolism.

Seventy-seven patients with MS and 44 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, diffusion tensor imaging, perfusion weighted imaging, and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures. In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures.