Reply:

Thank you for providing an opportunity to respond to the 2 letters, the first by Drs Gust and Ishak and the second by Dr Nabavizadeh. Our article focused on imaging findings of neurotoxicity of chimeric antigen receptor T-cell (CAR-T) therapy, an important new therapy for B-cell malignancies. As collective experience increases, so will reporting and understanding the imaging findings. Most published imaging findings of toxicity are in nonimaging journals. Adult neurotoxicity imaging findings were reported in Cancer Discovery in December 2017 by Gust et al;¹ Cancer Discovery in June 2018 by Santomasso et al;² and CNS Drugs in November 2018.³ Subsequent to our May 2019 publication in the American Journal of Neuroradiology, Annals of Neurology published findings by Gust et al⁴ in children and young adults in July 2019 and recently Brain, in May 2019, reported findings of acute stroke and hemorrhage.⁵ As imaging findings of neurotoxicity are identified and published, neuroradiologists and the imaging community will benefit from continued interest and publication in this area.

• © 2019 by American Journal of Neuroradiology