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Research ArticleInterventional

Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy in Intracranial ICA Occlusion

B.H. Baek, Y.Y. Lee, S.K. Kim and W. Yoon
American Journal of Neuroradiology August 2019, 40 (8) 1349-1355; DOI: https://doi.org/10.3174/ajnr.A6126
B.H. Baek
aFrom the Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
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Y.Y. Lee
aFrom the Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
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S.K. Kim
aFrom the Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
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W. Yoon
aFrom the Department of Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
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  • Fig 1.
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    Fig 1.

    A 74-year-old female patient with acute stroke due to acute intracranial ICA occlusion. DWI (A and B) shows acute infarctions involving the left medial temporal lobe (arrows), left internal capsule (arrowheads), and other parts of left temporal lobe. C, A delayed-phase radiograph obtained after a left ICA angiographic run shows complete occlusion (arrow) at the distal intracranial portion of the left ICA. D, Left ICA angiogram obtained after stent-retriever thrombectomy shows complete recanalization of the left ICA with good distal perfusion. E, Gradient-echo MR image obtained 1 day after thrombectomy shows parenchymal hematomas in the left medial temporal lobe (black arrow) and other parts of the left temporal lobe (white arrows).

  • Fig 2.
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    Fig 2.

    Distribution of mRS scores at 90 days according to the presence or absence of anterior choroidal artery infarction after thrombectomy in patients with acute intracranial ICA occlusion.

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    Fig 3.

    Distribution of mRS scores at 90 days, according to the reperfusion status after thrombectomy in patients with acute intracranial ICA occlusion.

Tables

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    Table 1:

    Comparison of characteristics according to the presence or absence of anterior choroidal artery infarction on pretreatment DWIa

    All Patients (n = 113)Positive for Anterior Choroidal Artery Infarction (n = 60)Negative for Anterior Choroidal Artery Infarction (n = 53)P
    Age (yr)74 (63–78)73 (62.25–78)74 (65–80.50).152
    Sex, male53 (46.9)26 (43.3)27 (50.9).419
    Risk factors
        Hypertension76 (67.3)41 (68.3)35 (66).795
        Diabetes mellitus31 (27.4)20 (33.3)11 (20.8).135
        Dyslipidemia31 (27.4)16 (26.7)15 (28.3).846
        Smoking25 (22.1)8 (13.3)17 (32.1).017
        Atrial fibrillation69 (61.1)38 (63.3)31 (58.5).598
        Coronary artery disease19 (16.8)10 (16.7)9 (16.9).964
        Previous stroke or TIA16 (14.2)7 (11.7)9 (16.9).419
        Congestive heart failure7 (6.2)4 (6.7)3 (5.7)1.000
    Intravenous thrombolysis60 (53.1)35 (58.3)25 (47.2).235
    DWI-ASPECTS7 (5–8)6 (4–8)7 (5.5–8).059
    Time to puncture (median) (IQR) (min)220 (160–290)205 (151.25–297.50)240 (179–298).211
    Procedure duration (min)35 (25–50)35 (25–50)42 (23–53.5).490
    Time to reperfusion (min)253 (197–337)236.50 (186.25–332.00)282 (206.5–350).214
    Baseline NIHSS score14 (11–17)14 (12–17)15 (10–17).701
    Underlying intracranial atherosclerotic stenosis12 (10.6)4 (6.7)8 (15.1).221
    Cervical ICA tandem occlusion10 (8.8)3 (5)7 (13.2).185
    Stroke subtype.509
        Cardioembolism74 (65.5)42 (70)32 (60.4)
        Large-artery atherosclerosis18 (15.9)6 (10)12 (22.6)
        Undetermined19 (16.8)12 (20)7 (13.2)
        Other2 (1.8)02 (3.8)
    • Note:—IQR indicates interquartile range.

    • ↵a Values are presented as No. (%) or median (IQR).

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    Table 2:

    Comparison of treatment outcomes between patients with and without anterior choroidal artery infarctiona

    All Patients (n = 113)Positive for Anterior Choroidal Artery Infarction (n = 60)Negative for Anterior Choroidal Artery Infarction (n = 53)P
    Successful reperfusion89 (78.8)45 (75)44 (83.0).298
    90-Day mRS 0–241 (37.2)15 (25)26 (49.1).008
    Parenchymal hemorrhage8 (7.1)8 (13.3)0.007
    Symptomatic hemorrhage4 (3.5)4 (6.7)0.121
    90-Day mortality12 (10.6)6 (10)6 (11.3).820
    • ↵a Values are presented as No. (%).

    • View popup
    Table 3:

    Comparison of characteristics between patients with good and poor outcomesa

    All Patients (n = 113)Good Outcome (n = 41)Poor Outcome (n = 72)P
    Age (yr)74 (63–78)70 (62–77.5)74 (64–79.75).105
    Sex, male53 (46.9)21 (51.2)32 (44.4).488
    Risk factors
        Hypertension76 (67.3)27 (65.9)49 (68.1).810
        Diabetes mellitus31 (27.4)8 (19.5)23 (31.9).154
        Dyslipidemia31 (27.4)13 (31.7)18 (25).442
        Smoking25 (22.1)12 (29.3)13 (18.1).167
        Atrial fibrillation69 (61.1)21 (51.2)48 (66.7).105
        Coronary artery disease19 (16.8)10 (24.4)9 (12.5).104
        Previous stroke or TIA16 (14.2)6 (14.6)10 (13.9).913
        Congestive heart failure7 (6.2)4 (9.8)3 (4.2).253
    Intravenous thrombolysis60 (53.1)21 (51.2)39 (54.2).763
    Anterior choroidal artery infarction on DWI60 (53.1)15 (36.6)45 (62.5).008
    DWI-ASPECTS7 (5–8)7 (5–9)6 (5–8).044
    Time to procedure (min)220 (160–290)225 (138.5–292.5)220 (161.25–297.5).770
    Procedural time (min)35 (25–50)30 (20–45)43 (27.25–58.75).023
    Time to reperfusion (min)253 (197–337)252 (173–338)258 (200.75–358).429
    Baseline NIHSS score14 (11–17)13 (10–17)15 (12–17).182
    Underlying severe intracranial stenosis12 (10.6)8 (19.5)4 (5.6).028
    Cervical ICA tandem occlusion10 (8.8)3 (7.3)7 (9.7).745
    Stroke etiology.411
        Cardioembolism74 (65.5)24 (58.5)50 (69.4)
        Large-artery atherosclerosis18 (15.9)10 (24.4)8 (11.1)
        Undetermined19 (16.8)5 (12.2)14 (19.4)
        Other2 (1.8)2 (4.9)0
    Successful reperfusion89 (78.8)39 (95.1)50 (69.4).001
    Parenchymal hemorrhage8 (7.1)08 (11.1).049
    Symptomatic hemorrhage4 (3.5)04 (5.6).295
    • ↵a Values are presented as No. (%) or median (IQR).

    • View popup
    Table 4:

    Univariate and multivariate binary logistic regression analysis for predictors of good 90-day outcome

    VariableUnadjusted OR (95% CI)PAdjusted OR (95% CI)P
    Age, per 1-year increase0.975 (0.942–1.009).149––
    Baseline NIHSS score, per 1-point increase0.922 (0.834–1.019).112––
    Anterior choroidal artery infarction0.346 (0.156–0.766).0090.333 (0.135–0.824).017
    DWI-ASPECTS, per 1-point increase1.232 (1.004–1.511).046––
    Procedure duration, per 1-min increase0.980 (0.961–1.000).047––
    Underlying severe intracranial stenosis4.121 (1.157–14.678).029––
    Successful reperfusion8.580 (1.901–38.718).0055.598 (1.135–27.604).034
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American Journal of Neuroradiology: 40 (8)
American Journal of Neuroradiology
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1 Aug 2019
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Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy in Intracranial ICA Occlusion
B.H. Baek, Y.Y. Lee, S.K. Kim, W. Yoon
American Journal of Neuroradiology Aug 2019, 40 (8) 1349-1355; DOI: 10.3174/ajnr.A6126

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Pretreatment Anterior Choroidal Artery Infarction Predicts Poor Outcome after Thrombectomy in Intracranial ICA Occlusion
B.H. Baek, Y.Y. Lee, S.K. Kim, W. Yoon
American Journal of Neuroradiology Aug 2019, 40 (8) 1349-1355; DOI: 10.3174/ajnr.A6126
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