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This article is an overview of the updated version of the RANO 2.0 criteria, which are a standardized determination of radiographic response in adult gliomas on clinical trials. It provides guidance on the criteria for high- and low-grade gliomas in adults, use of the postradiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas, the option of using volumetric tumor measurements, and the removal of subjective nonenhancing tumor evaluations in predominantly enhancing gliomas.