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Abstract

MR of Neuronal Migration Anomalies

A. James Barkovich, Sylvester H. Chuang and David Norman
American Journal of Neuroradiology November 1987, 8 (6) 1009-1017;
A. James Barkovich
1Department of Radiology, Letterman Army Medical Center, Presidio of San Francisco, CA 94129-6700. Address reprint requests to Technical Publications Editor HSHH-ZCT
2Department of Radiology, Neuroradiology Section, University of California School of Medicine, San Francisco, CA 94143
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Sylvester H. Chuang
3Department of Radiology, Neuroradiology Section, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
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David Norman
2Department of Radiology, Neuroradiology Section, University of California School of Medicine, San Francisco, CA 94143
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Abstract

Migration anomalies are congenital malformations caused by insults to migrating neuroblasts during the third to fifth gestational months. Included in this group are agyria, pachygyria, polymicrogyria, unilateral megalencephaly, schizencephaly, and gray matter heterotopias. Patients who have these conditions present clinically with developmental delay and seizures, and abnormal motor skills are noted in the more severely affected infants. To determine the utility of MR as a method for imaging in these patients, we used MR to evaluate 13 patients who had the full spectrum of migration anomalies. MR was more sensitive than CT in detecting these anomalies because of its better contrast between gray and white matter. We found that MR was particularly more sensitive in detecting schizencephaly, where recognizing the presence of gray matter lining the cleft is critical to distinguishing that disease from porencephaly, and in detecting polymicrogyria, where critical details of cortical architecture are obscured on CT by the overlying bone. Multiplanar capabilities were also found to be essential, since narrow clefts may not be detected when the imaging plane is parallel to the cleft.

MR should be the primary imaging method for infants who have seizures or developmental delay.

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American Journal of Neuroradiology
Vol. 8, Issue 6
1 Nov 1987
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MR of Neuronal Migration Anomalies
A. James Barkovich, Sylvester H. Chuang, David Norman
American Journal of Neuroradiology Nov 1987, 8 (6) 1009-1017;

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MR of Neuronal Migration Anomalies
A. James Barkovich, Sylvester H. Chuang, David Norman
American Journal of Neuroradiology Nov 1987, 8 (6) 1009-1017;
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