More articles from Adult Brain
- Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration
This is a retrospective review of the medical records of 706 consecutive patients who were treated with irradiation for primary brain tumors at The Johns Hopkins Medical Institutions between June 1995–January 2010. The authors found that the appearance of hyperintense dentate nuclei (HDN) is likely permanent, given the long follow-up time of the study, and a significant association between HDN and repeated contrast-enhanced MR studies. A significant increase in the likelihood of HDN occurred after 4 or more enhanced scans, and total dose of 77 ml of gadolinium contrast agent. They found no association between radiation exposure and HDN.
- Repeatability of Standardized and Normalized Relative CBV in Patients with Newly Diagnosed Glioblastoma
Relative CBV estimates were calculated from dynamic susceptibility contrast MR imaging in double-baseline examinations of 33 patients with treatment-naïve and pathologically proved glioblastoma multiforme. Normalized and standardized relative CBV were calculated by using 6 common postprocessing methods. The ΔR2* estimation method that incorporates leakage correction offers the best repeatability for rCBV, with standardized rCBV being less variable.
- The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
The authors performed a crossover, intraindividual comparison of 0.1-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 1) and 0.05-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 2). In Arm 1, a significant superiority of 0.1-mmol/kg gadobenate was demonstrated by all readers for all end points. In Arm 2, no significant differences were observed for any reader and any end point, with the exception of percentage enhancement for reader 2 in favor of 0.05-mmol/kg gadobenate.