Research ArticleRESEARCH PERSPECTIVES
Open Access
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga and M.W. Vernooij
American Journal of Neuroradiology June 2015, DOI: https://doi.org/10.3174/ajnr.A4409
C.A. Raji
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
H. Eyre
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
S.H. Wei
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
D.E. Bredesen
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
S. Moylan
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
M. Law
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
G. Small
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
P.M. Thompson
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
R.M. Friedlander
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
D.H. Silverman
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
B.T. Baune
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
T.A. Hoang
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
N. Salamon
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
A.W. Toga
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
M.W. Vernooij
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
Abstract
SUMMARY: Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.
Abbreviations
- AD
- Alzheimer disease
- APOE
- Apolipoprotein E
- BMI
- body mass index
- MCI
- mild cognitive impairment
- © 2015 American Society of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org
Advertisement
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409
Jump to section
Related Articles
- No related articles found.
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Pauline H. Croll, Trudy Voortman, M. Arfan Ikram, Oscar H. Franco, Josje D. Schoufour, Daniel Bos, Meike W. VernooijNeurology 2018 90 24
- Jamila Ahdidan, Cyrus A. Raji, Edgar A. DeYoe, Jedidiah Mathis, Karsten Ø. Noe, Jens Rimestad, Thomas K. Kjeldsen, Jesper Mosegaard, James T. Becker, Oscar LopezJournal of Alzheimer's Disease 2015 49 3
- J. Richard Jennings, Matthew F. Muldoon, Christopher Ryan, H. Michael Gach, Alicia Heim, Lei K. Sheu, Peter J. GianarosJournal of the American Heart Association 2017 6 3
- Harris A. Eyre, Helen Lavretsky, Malcolm Forbes, Cyrus Raji, Gary Small, Patrick McGorry, Bernhard T. Baune, Charles ReynoldsAcademic Psychiatry 2017 41 1
- Frank C. G. van Bussel, Walter H. Backes, Paul A. M. Hofman, Robert J. van Oostenbrugge, Martin P. J. van Boxtel, Frans R. J. Verhey, Harry W. M. Steinbusch, Miranda T. Schram, Coen D. A. Stehouwer, Joachim E. Wildberger, Jacobus F. A. JansenFrontiers in Neuroscience 2017 11
- D. Collazos-Huertas, D. Cárdenas-Peña, G. Castellanos-DominguezInternational Journal of Neural Systems 2019 29 02
- Wiro J. NiessenMedical Image Analysis 2016 33
- Natalie A. Emmert, Katherine E. Reiter, Alissa Butts, Julie K Janecek, Mohit Agarwal, Malgorzata Franczak, James Reuss, Andrew Klein, Yang Wang, Laura Glass UmfleetJournal of the International Neuropsychological Society 2022 28 4
- Zhen-Zhi Wang, Zhen Sun, Mei-Ling Zhang, Kang Xiong, Feng ZhouFrontiers in Neurology 2022 13
More in this TOC Section
Similar Articles
Advertisement