Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleRESEARCH PERSPECTIVES
Open Access

Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline

C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga and M.W. Vernooij
American Journal of Neuroradiology June 2015, DOI: https://doi.org/10.3174/ajnr.A4409
C.A. Raji
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. Eyre
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.H. Wei
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.E. Bredesen
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Moylan
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Law
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Small
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.M. Thompson
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.M. Friedlander
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.H. Silverman
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.T. Baune
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.A. Hoang
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Salamon
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.W. Toga
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.W. Vernooij
From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.), Psychiatry (H.E., G.S.), Neurology (D.E.B.), and Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California; Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia; School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia; Department of Radiology (M.L.) and Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California; Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

SUMMARY: Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.

Abbreviations

AD
Alzheimer disease
APOE
Apolipoprotein E
BMI
body mass index
MCI
mild cognitive impairment
  • © 2015 American Society of Neuroradiology

Indicates open access to non-subscribers at www.ajnr.org

Next
Back to top
Advertisement
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij
American Journal of Neuroradiology Jun 2015, DOI: 10.3174/ajnr.A4409
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Better diet quality relates to larger brain tissue volumes: The Rotterdam Study
  • Prehypertensive Blood Pressures and Regional Cerebral Blood Flow Independently Relate to Cognitive Performance in Midlife
  • Crossref (11)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Better diet quality relates to larger brain tissue volumes
    Pauline H. Croll, Trudy Voortman, M. Arfan Ikram, Oscar H. Franco, Josje D. Schoufour, Daniel Bos, Meike W. Vernooij
    Neurology 2018 90 24
  • Quantitative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR Imaging
    Jamila Ahdidan, Cyrus A. Raji, Edgar A. DeYoe, Jedidiah Mathis, Karsten Ø. Noe, Jens Rimestad, Thomas K. Kjeldsen, Jesper Mosegaard, James T. Becker, Oscar Lopez
    Journal of Alzheimer's Disease 2015 49 3
  • Prehypertensive Blood Pressures and Regional Cerebral Blood Flow Independently Relate to Cognitive Performance in Midlife
    J. Richard Jennings, Matthew F. Muldoon, Christopher Ryan, H. Michael Gach, Alicia Heim, Lei K. Sheu, Peter J. Gianaros
    Journal of the American Heart Association 2017 6 3
  • Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging
    Frank C. G. van Bussel, Walter H. Backes, Paul A. M. Hofman, Robert J. van Oostenbrugge, Martin P. J. van Boxtel, Frans R. J. Verhey, Harry W. M. Steinbusch, Miranda T. Schram, Coen D. A. Stehouwer, Joachim E. Wildberger, Jacobus F. A. Jansen
    Frontiers in Neuroscience 2017 11
  • Convergence Science Arrives: How Does It Relate to Psychiatry?
    Harris A. Eyre, Helen Lavretsky, Malcolm Forbes, Cyrus Raji, Gary Small, Patrick McGorry, Bernhard T. Baune, Charles Reynolds
    Academic Psychiatry 2017 41 1
  • Instance-Based Representation Using Multiple Kernel Learning for Predicting Conversion to Alzheimer Disease
    D. Collazos-Huertas, D. Cárdenas-Peña, G. Castellanos-Dominguez
    International Journal of Neural Systems 2019 29 02
  • MR brain image analysis in dementia: From quantitative imaging biomarkers to ageing brain models and imaging genetics
    Wiro J. Niessen
    Medical Image Analysis 2016 33
  • Hippocampal Volumes in Amnestic and Non-Amnestic Mild Cognitive Impairment Types Using Two Common Methods of MCI Classification
    Natalie A. Emmert, Katherine E. Reiter, Alissa Butts, Julie K Janecek, Mohit Agarwal, Malgorzata Franczak, James Reuss, Andrew Klein, Yang Wang, Laura Glass Umfleet
    Journal of the International Neuropsychological Society 2022 28 4
  • Handbook of Mental Health and Aging
    Meghan Riddle, Warren D. Taylor
    2020
  • Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study
    Pallavi Nair, Kameshwar Prasad, Parthiban Balasundaram, Deepti Vibha, Sada Nand Dwivedi, Shailesh B. Gaikwad, Achal K. Srivastava, Vivek Verma
    Aging Brain 2023 3

More in this TOC Section

  • Evidence Levels for Neuroradiology Articles: Low Agreement among Raters
  • Imaging Biomarkers in Ischemic Stroke Clinical Trials: An Opportunity for Rigor
Show more RESEARCH PERSPECTIVES

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire