Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Review ArticleREVIEW ARTICLE
Open Access

Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety

C. McNamara, G. Sugrue, B. Murray and P.J. MacMahon
American Journal of Neuroradiology April 2017, DOI: https://doi.org/10.3174/ajnr.A5147
C. McNamara
From the Departments of Radiology (C.M., G.S., P.J.M.) and Neurology (B.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. McNamara
G. Sugrue
From the Departments of Radiology (C.M., G.S., P.J.M.) and Neurology (B.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Sugrue
B. Murray
From the Departments of Radiology (C.M., G.S., P.J.M.) and Neurology (B.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Murray
P.J. MacMahon
From the Departments of Radiology (C.M., G.S., P.J.M.) and Neurology (B.M.), Mater Misericordiae University Hospital, Dublin, Ireland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.J. MacMahon
  • Article
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Abstract

SUMMARY: Imaging for the diagnosis and follow-up of patients with suspected or confirmed multiple sclerosis is a common scenario for many general radiologists and subspecialty neuroradiologists. The field of MS therapeutics has rapidly evolved with multiple new agents now being used in routine clinical practice. To provide an informed opinion in discussions concerning newer MS agents, radiologists must have a working understanding of the strengths and limitations of the various novel therapies. The role of imaging in MS has advanced beyond monitoring and surveillance of disease activity to include treatment complications. An understanding of the new generation of MS drugs in conjunction with the key role that MR imaging plays in the detection of disease progression, opportunistic infections, and drug-related adverse events is of vital importance to the radiologist and clinical physician alike. Radiologists are in a unique position to detect many of the described complications well in advance of clinical symptoms. Part 1 of this review outlines recent developments in the treatment of MS and discusses the published clinical data on the efficacy and safety of the currently approved and emerging therapies in this condition as they apply to the radiologist. Part 2 will cover pharmacovigilance and the role the neuroradiologist plays in monitoring patients for signs of opportunistic infection and/or disease progression.

Abbreviations

IFNβ
interferon β
NTZ
natalizumab
PML
progressive multifocal leukoencephalopathy
RRMS
relapsing-remitting MS
  • © 2017 American Society of Neuroradiology

Indicates open access to non-subscribers at www.ajnr.org

Next
Back to top
Advertisement
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety
C. McNamara, G. Sugrue, B. Murray, P.J. MacMahon
American Journal of Neuroradiology Apr 2017, DOI: 10.3174/ajnr.A5147

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Current and Emerging Therapies in Multiple Sclerosis: Implications for the Radiologist, Part 1—Mechanisms, Efficacy, and Safety
C. McNamara, G. Sugrue, B. Murray, P.J. MacMahon
American Journal of Neuroradiology Apr 2017, DOI: 10.3174/ajnr.A5147
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Improved Detection of New MS Lesions during Follow-Up Using an Automated MR Coregistration-Fusion Method
  • Crossref (6)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Improved Detection of New MS Lesions during Follow-Up Using an Automated MR Coregistration-Fusion Method
    A. Galletto Pregliasco, A. Collin, A. Guéguen, M.A. Metten, J. Aboab, R. Deschamps, O. Gout, L. Duron, J.C. Sadik, J. Savatovsky, A. Lecler
    American Journal of Neuroradiology 2018 39 7
  • Radiopaedia.org
    Derek Smith, Frank Gaillard
    2008
  • The ethical matrix as a method for involving people living with disease and the wider public (PPI) in near-term artificial intelligence research
    B.S. Kelly, A. Kirwan, M.S. Quinn, A.M. Kelly, P. Mathur, A. Lawlor, R.P. Killeen
    Radiography 2023 29
  • A unified framework for focal intensity change detection and deformable image registration. Application to the monitoring of multiple sclerosis lesions in longitudinal 3D brain MRI
    Eléonore Dufresne, Denis Fortun, Stéphane Kremer, Vincent Noblet
    Frontiers in Neuroimaging 2022 1
  • Contrast-Enhanced 3D Spin Echo T1-Weighted Sequence Outperforms 3D Gradient Echo T1-Weighted Sequence for the Detection of Multiple Sclerosis Lesions on 3.0 T Brain MRI
    Ariane de Panafieu, Augustin Lecler, Adrien Goujon, Sidney Krystal, Antoine Gueguen, Jean-Claude Sadik, Julien Savatovsky, Loïc Duron
    Investigative Radiology 2023 58 5
  • Medical Image Computing and Computer Assisted Intervention – MICCAI 2021
    Minh-Son To, Ian G. Sarno, Chee Chong, Mark Jenkinson, Gustavo Carneiro
    2021 12907

More in this TOC Section

REVIEW ARTICLE

  • Advances in Acute Ischemic Stroke Treatment: Current Status and Future Directions
  • Comprehensive Update and Review of Clinical and Imaging Features of SMART Syndrome
  • Head CT: Toward Making Full Use of the Information the X-Rays Give
Show more REVIEW ARTICLE

ADULT BRAIN

  • Automated Segmentation of Intracranial Thrombus on NCCT and CTA in Patients with Acute Ischemic Stroke Using a Coarse-to-Fine Deep Learning Model
  • NCCT Markers of Intracerebral Hemorrhage Expansion Using Revised Criteria: An External Validation of Their Predictive Accuracy
  • Deep Learning of Time–Signal Intensity Curves from Dynamic Susceptibility Contrast Imaging Enables Tissue Labeling and Prediction of Survival in Glioblastoma
Show more ADULT BRAIN

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire