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Research ArticleSPINE

Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery

W. Coenen, C. Gutiérrez-Montes, S. Sincomb, E. Criado-Hidalgo, K. Wei, K. King, V. Haughton, C. Martínez-Bazán, A.L. Sánchez and J. C. Lasheras
American Journal of Neuroradiology June 2019, DOI: https://doi.org/10.3174/ajnr.A6097
W. Coenen
aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
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C. Gutiérrez-Montes
cDepartment of Mechanical and Mining Engineering (C.G.-M., C.M.-B.), University of Jaén, Jaén, Andalucía, Spain
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S. Sincomb
aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
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E. Criado-Hidalgo
aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
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K. Wei
dMRI Center (K.W., K.K.), Huntington Medical Research Institutes, Pasadena, California
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K. King
dMRI Center (K.W., K.K.), Huntington Medical Research Institutes, Pasadena, California
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V. Haughton
eDepartment of Radiology (V.H.), School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
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C. Martínez-Bazán
cDepartment of Mechanical and Mining Engineering (C.G.-M., C.M.-B.), University of Jaén, Jaén, Andalucía, Spain
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A.L. Sánchez
aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
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J. C. Lasheras
aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
bBioengineering (J.C.L.), University of California, San Diego, San Diego, California
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A6097
PubMed 
31196863

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 22, 2019
  • Accepted after revision May 8, 2019
  • Published online June 13, 2019.

Article Versions

  • You are currently viewing a Latest version of this article (June 13, 2019 - 07:00).
  • View the most recent version of this article
Copyright & Usage 
© 2019 by American Journal of Neuroradiology

Author Information

  1. W. Coenena,
  2. C. Gutiérrez-Montesc,
  3. S. Sincomba,
  4. E. Criado-Hidalgoa,
  5. K. Weid,
  6. K. Kingd,
  7. V. Haughtone,
  8. C. Martínez-Bazánc,
  9. A.L. Sáncheza and
  10. J. C. Lasherasa,b
  1. aFrom the Departments of Mechanical and Aerospace Engineering (W.C., S.S., E.C.-H., A.L.S., J.C.L.)
  2. bBioengineering (J.C.L.), University of California, San Diego, San Diego, California
  3. cDepartment of Mechanical and Mining Engineering (C.G.-M., C.M.-B.), University of Jaén, Jaén, Andalucía, Spain
  4. dMRI Center (K.W., K.K.), Huntington Medical Research Institutes, Pasadena, California
  5. eDepartment of Radiology (V.H.), School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
  1. Please address correspondence to Wilfried Coenen, PhD, Department of Mechanical and Aerospace Engineering, University of California San Diego, 9500 Gilman Dr, No. 0411, La Jolla, CA 92093; e-mail: wicoenen{at}ucsd.edu
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  • A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal
    S. Sincomb, W. Coenen, C. Gutiérrez-Montes, C. Martínez Bazán, V. Haughton, A.L. Sánchez
    Journal of Fluid Mechanics 2022 939
  • Modelling and direct numerical simulation of flow and solute dispersion in the spinal subarachnoid space
    C. Gutiérrez-Montes, W. Coenen, J.J. Lawrence, C. Martínez-Bazán, A.L. Sánchez, J.C. Lasheras
    Applied Mathematical Modelling 2021 94
  • Cerebrospinal Fluid Flow
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    Annual Review of Fluid Mechanics 2023 55 1
  • Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient
    Jose De Andres, Salim Hayek, Christophe Perruchoud, Melinda M. Lawrence, Miguel Angel Reina, Carmen De Andres-Serrano, Ruben Rubio-Haro, Mathew Hunt, Tony L. Yaksh
    Frontiers in Pain Research 2022 3
  • Assessing Cerebrospinal Fluid Flow Dynamics in Pediatric Patients with Central Nervous System Tumors Treated with Intraventricular Radioimmunotherapy
    Kim Kramer, Maria Donzelli, Emmanuela Nwora, Neeta Pandit-Taskar
    Journal of Nuclear Medicine 2020 61 5
  • Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space
    C. Gutiérrez-Montes, W. Coenen, M. Vidorreta, S. Sincomb, C. Martínez-Bazán, A.L. Sánchez, V. Haughton
    American Journal of Neuroradiology 2022 43 9
  • Buoyancy-modulated Lagrangian drift in wavy-walled vertical channels as a model problem to understand drug dispersion in the spinal canal
    J. Alaminos-Quesada, W. Coenen, C. Gutiérrez-Montes, A.L. Sánchez
    Journal of Fluid Mechanics 2022 949
  • In vitro characterization of solute transport in the spinal canal
    F. Moral-Pulido, J. I. Jiménez-González, C. Gutiérrez-Montes, W. Coenen, A. L. Sánchez, C. Martínez-Bazán
    Physics of Fluids 2023 35 5
  • A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides
    Andreas A. Linninger, Dipak Barua, Yaming Hang, Sergio Iadevaia, Majid Vakilynejad
    Frontiers in Physiology 2023 14
  • Oscillating viscous flow past a streamwise linear array of circular cylinders
    J. Alaminos-Quesada, J.J. Lawrence, W. Coenen, A.L. Sánchez
    Journal of Fluid Mechanics 2023 959
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Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery
W. Coenen, C. Gutiérrez-Montes, S. Sincomb, E. Criado-Hidalgo, K. Wei, K. King, V. Haughton, C. Martínez-Bazán, A.L. Sánchez, J. C. Lasheras
American Journal of Neuroradiology Jun 2019, DOI: 10.3174/ajnr.A6097

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Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery
W. Coenen, C. Gutiérrez-Montes, S. Sincomb, E. Criado-Hidalgo, K. Wei, K. King, V. Haughton, C. Martínez-Bazán, A.L. Sánchez, J. C. Lasheras
American Journal of Neuroradiology Jun 2019, DOI: 10.3174/ajnr.A6097
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Cited By...

  • Assessing Cerebrospinal Fluid Flow Dynamics in Pediatric Patients with Central Nervous System Tumors Treated with Intraventricular Radioimmunotherapy
  • Crossref (10)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal
    S. Sincomb, W. Coenen, C. Gutiérrez-Montes, C. Martínez Bazán, V. Haughton, A.L. Sánchez
    Journal of Fluid Mechanics 2022 939
  • Modelling and direct numerical simulation of flow and solute dispersion in the spinal subarachnoid space
    C. Gutiérrez-Montes, W. Coenen, J.J. Lawrence, C. Martínez-Bazán, A.L. Sánchez, J.C. Lasheras
    Applied Mathematical Modelling 2021 94
  • Cerebrospinal Fluid Flow
    Douglas H. Kelley, John H. Thomas
    Annual Review of Fluid Mechanics 2023 55 1
  • Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient
    Jose De Andres, Salim Hayek, Christophe Perruchoud, Melinda M. Lawrence, Miguel Angel Reina, Carmen De Andres-Serrano, Ruben Rubio-Haro, Mathew Hunt, Tony L. Yaksh
    Frontiers in Pain Research 2022 3
  • Assessing Cerebrospinal Fluid Flow Dynamics in Pediatric Patients with Central Nervous System Tumors Treated with Intraventricular Radioimmunotherapy
    Kim Kramer, Maria Donzelli, Emmanuela Nwora, Neeta Pandit-Taskar
    Journal of Nuclear Medicine 2020 61 5
  • Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space
    C. Gutiérrez-Montes, W. Coenen, M. Vidorreta, S. Sincomb, C. Martínez-Bazán, A.L. Sánchez, V. Haughton
    American Journal of Neuroradiology 2022 43 9
  • Buoyancy-modulated Lagrangian drift in wavy-walled vertical channels as a model problem to understand drug dispersion in the spinal canal
    J. Alaminos-Quesada, W. Coenen, C. Gutiérrez-Montes, A.L. Sánchez
    Journal of Fluid Mechanics 2022 949
  • In vitro characterization of solute transport in the spinal canal
    F. Moral-Pulido, J. I. Jiménez-González, C. Gutiérrez-Montes, W. Coenen, A. L. Sánchez, C. Martínez-Bazán
    Physics of Fluids 2023 35 5
  • A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides
    Andreas A. Linninger, Dipak Barua, Yaming Hang, Sergio Iadevaia, Majid Vakilynejad
    Frontiers in Physiology 2023 14
  • Oscillating viscous flow past a streamwise linear array of circular cylinders
    J. Alaminos-Quesada, J.J. Lawrence, W. Coenen, A.L. Sánchez
    Journal of Fluid Mechanics 2023 959

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