Research ArticlePEDIATRIC NEUROIMAGING
Enzyme Replacement Therapy for CLN2 Disease: MRI Volumetry Shows Significantly Slower Volume Loss Compared with a Natural History Cohort
Pritika Gaur, Paul Gissen, Asthik Biswas, Kshitij Mankad, Sniya Sudhakar, Felice D’Arco, Angela Schulz, Jens Fiehler, Jan Sedlacik and Ulrike Löbel
American Journal of Neuroradiology October 2024, DOI: https://doi.org/10.3174/ajnr.A8408
Pritika Gaur
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
Paul Gissen
bNational Institute for Health Research (P. Gissen), Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK
Asthik Biswas
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
Kshitij Mankad
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
Sniya Sudhakar
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
Felice D’Arco
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
Angela Schulz
cDepartment of Paediatrics (A.S.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
gGerman Center for Child and Adolescent Health (A.S.), Partner Site Hamburg, Hamburg, Germany
Jens Fiehler
dDepartment of Diagnostic and Interventional Neuroradiology (J.F.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Jan Sedlacik
eRobert Steiner MR Facility (J.S.), Medical Research Council Laboratory of Medical Sciences, Hammersmith Hospital Campus, London, UK
fMansfield Centre for Innovation (J.S.), Imaging Sciences, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK
Ulrike Löbel
aFrom the Department of Radiology (P. Gaur, A.B., K.M., S.S., F.D., U.L.), Great Ormond Street Hospital, London, UK
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Enzyme Replacement Therapy for CLN2 Disease: MRI Volumetry Shows Significantly Slower Volume Loss Compared with a Natural History Cohort
Pritika Gaur, Paul Gissen, Asthik Biswas, Kshitij Mankad, Sniya Sudhakar, Felice D’Arco, Angela Schulz, Jens Fiehler, Jan Sedlacik, Ulrike Löbel
American Journal of Neuroradiology Oct 2024, DOI: 10.3174/ajnr.A8408
Enzyme Replacement Therapy for CLN2 Disease: MRI Volumetry Shows Significantly Slower Volume Loss Compared with a Natural History Cohort
Pritika Gaur, Paul Gissen, Asthik Biswas, Kshitij Mankad, Sniya Sudhakar, Felice D’Arco, Angela Schulz, Jens Fiehler, Jan Sedlacik, Ulrike Löbel
American Journal of Neuroradiology Oct 2024, DOI: 10.3174/ajnr.A8408
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