Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Quality, Safety, and Value Special Collection
    • ASFNR Stroke Perfusion Special Collection
    • ASNR Foundation Special Collection
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • Low-Field MRI
    • Alzheimer Disease
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Author Policies
    • Peer-Review Policy
    • Transparency in Authorship Policy
    • Conflict-of-Interest Policy
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Quality, Safety, and Value Special Collection
    • ASFNR Stroke Perfusion Special Collection
    • ASNR Foundation Special Collection
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • Low-Field MRI
    • Alzheimer Disease
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Author Policies
    • Peer-Review Policy
    • Transparency in Authorship Policy
    • Conflict-of-Interest Policy
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Check out our Case Collections, Special Collections, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleSPINE IMAGING AND SPINE IMAGE-GUIDED INTERVENTIONS

Multiple Synchronous CSF-Venous Fistulas in Spontaneous Intracranial Hypotension: A Multi-Institutional Case Series

Ajay A. Madhavan, Timothy J. Amrhein, Michelle L. Kodet, Niklas Lützen, Michael Malinzak, Jeremy K. Cutsforth-Gregory, Ian T. Mark, Ivan Garza, Eike I. Piechowiak and Lalani Carlton Jones
American Journal of Neuroradiology November 2025, DOI: https://doi.org/10.3174/ajnr.A8900
Ajay A. Madhavan
aFrom the Department of Radiology (A.A.M., M.L.K., I.T.M.), Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ajay A. Madhavan
Timothy J. Amrhein
bDepartment of Radiology (T.J.A., M.M.), Division of Neuroradiology, Duke Health, Durham, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Timothy J. Amrhein
Michelle L. Kodet
aFrom the Department of Radiology (A.A.M., M.L.K., I.T.M.), Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michelle L. Kodet
Niklas Lützen
cDepartment of Radiology (N.L., E.I.P.), University of Freiberg, Freiberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Malinzak
bDepartment of Radiology (T.J.A., M.M.), Division of Neuroradiology, Duke Health, Durham, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michael Malinzak
Jeremy K. Cutsforth-Gregory
dDepartment of Neurology (J.K.C.-G., I.G.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jeremy K. Cutsforth-Gregory
Ian T. Mark
aFrom the Department of Radiology (A.A.M., M.L.K., I.T.M.), Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ian T. Mark
Ivan Garza
dDepartment of Neurology (J.K.C.-G., I.G.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ivan Garza
Eike I. Piechowiak
cDepartment of Radiology (N.L., E.I.P.), University of Freiberg, Freiberg, Germany
eNeuroradiology (E.I.P.), Inselspital Universitatsspital Bern, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Eike I. Piechowiak
Lalani Carlton Jones
fDepartment of Radiology, Guys & St Thomas’s and Kings College Hospitals NHS Foundation Trusts (L.C.J.), London, United Kingdom
gInstitute of Psychiatry, Psychology and Neuroscience, Kings College London (L.C.J.), London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lalani Carlton Jones
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Graphical Abstract

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

SUMMARY:

CSF-venous fistulas (CVFs) are a common cause of spontaneous intracranial hypotension. Due to the more routine use of decubitus myelography and advancements in various imaging techniques, recognition of CVFs has increased in recent years. Most commonly, patients harbor only 1 fistula at the time of myelography (although additional de novo fistulas can arise after treatment). Occasionally, 2 synchronous CVFs may be seen on a single myelogram. The coexistence of more than 2 CVFs, however, is quite rare and has only been previously described in 2 instances. Here, we present a multi-institutional series of 16 patients with 3 or more concurrently discovered CVFs, representing the largest cohort of such patients to date. We describe their clinical features, imaging findings, treatment approaches, and outcomes.

ABBREVIATIONS:

CVF
CSF-venous fistula
CB-CTM
conebeam CT myelogram
DSM
digital subtraction myelography
EID
energy-integrating detector
PCD
photon-counting detector
SIH
spontaneous intracranial hypotension

Footnotes

  • Disclosure forms provided by the authors are available with the full text and PDF of this article at www.ajnr.org.

  • © 2025 by American Journal of Neuroradiology
View Full Text

ASNR members

ASNR Member Login

Login to the site using your ASNR member credentials

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Multiple Synchronous CSF-Venous Fistulas in Spontaneous Intracranial Hypotension: A Multi-Institutional Case Series
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Ajay A. Madhavan, Timothy J. Amrhein, Michelle L. Kodet, Niklas Lützen, Michael Malinzak, Jeremy K. Cutsforth-Gregory, Ian T. Mark, Ivan Garza, Eike I. Piechowiak, Lalani Carlton Jones
Multiple Synchronous CSF-Venous Fistulas in Spontaneous Intracranial Hypotension: A Multi-Institutional Case Series
American Journal of Neuroradiology Nov 2025, DOI: 10.3174/ajnr.A8900

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Multiple Synchronous CSF-Venous Fistulas
Ajay A. Madhavan, Timothy J. Amrhein, Michelle L. Kodet, Niklas Lützen, Michael Malinzak, Jeremy K. Cutsforth-Gregory, Ian T. Mark, Ivan Garza, Eike I. Piechowiak, Lalani Carlton Jones
American Journal of Neuroradiology Nov 2025, DOI: 10.3174/ajnr.A8900
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Graphical Abstract
    • SUMMARY:
    • ABBREVIATIONS:
    • CLINICAL REPORT
    • DISCUSSION
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Overutilization of Cord Compression MRI in the ED
  • Predictive Value of Negative Brain MRI in CSF-VF
  • Irregular Nerve Sheaths as a Mimic of CSF
Show more Spine Imaging and Spine Image-Guided Interventions

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Peer-Review Policy
  • Transparency in Authorship Policy
  • Conflict-of-Interest Policy
  • News and Updates
  • Become a Reviewer/Academy of Reviewers

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire