RT Journal Article
SR Electronic
T1 Quantitative MRI in Multiple Sclerosis: From Theory to Application
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1688
OP 1695
DO 10.3174/ajnr.A7536
VO 43
IS 12
A1 Tranfa, M.
A1 Pontillo, G.
A1 Petracca, M.
A1 Brunetti, A.
A1 Tedeschi, E.
A1 Palma, G.
A1 Cocozza, S.
YR 2022
UL http://www.ajnr.org/content/43/12/1688.abstract
AB SUMMARY: Quantitative MR imaging techniques allow evaluating different aspects of brain microstructure, providing meaningful information about the pathophysiology of damage in CNS disorders. In the study of patients with MS, quantitative MR imaging techniques represent an invaluable tool for studying changes in myelin and iron content occurring in the context of inflammatory and neurodegenerative processes. In the first section of this review, we summarize the physics behind quantitative MR imaging, here defined as relaxometry and quantitative susceptibility mapping, and describe the neurobiological correlates of quantitative MR imaging findings. In the second section, we focus on quantitative MR imaging application in MS, reporting the main findings in both the gray and white matter compartments, separately addressing macroscopically damaged and normal-appearing parenchyma.bSSFPbalanced steady-state free precessionCLcortical lesionsGREgradient recalled-echoNAWMnormal-appearing white matterPDproton densityqMRIquantitative MR imagingQSMquantitative susceptibility mappingRFradiofrequency