PT  - JOURNAL ARTICLE
AU  - N. Soni
AU  - M. Ora
AU  - A. Jena
AU  - P. Rana
AU  - R. Mangla
AU  - S. Ellika
AU  - J. Almast
AU  - S. Puri
AU  - S.P. Meyers
TI  - Amino Acid Tracer PET MRI in Glioma Management: What a Neuroradiologist Needs to Know
AID  - 10.3174/ajnr.A7762
DP  - 2023 Mar 01
TA  - American Journal of Neuroradiology
PG  - 236--246
VI  - 44
IP  - 3
4099  - http://www.ajnr.org/content/44/3/236.short
4100  - http://www.ajnr.org/content/44/3/236.full
SO  - Am. J. Neuroradiol.2023 Mar 01; 44
AB  - SUMMARY: PET with amino acid tracers provides additional insight beyond MR imaging into the biology of gliomas that can be used for initial diagnosis, delineation of tumor margins, planning of surgical and radiation therapy, assessment of residual tumor, and evaluation of posttreatment response. Hybrid PET MR imaging allows the simultaneous acquisition of various PET and MR imaging parameters in a single investigation with reduced scanning time and improved anatomic localization. This review aimed to provide neuroradiologists with a concise overview of the various amino acid tracers and a practical understanding of the clinical applications of amino acid PET MR imaging in glioma management. Future perspectives in newer advances, novel radiotracers, radiomics, and cost-effectiveness are also outlined.AATamino acid tracerAAamino acidASCTalanine-serine-cysteine transporterBTVbiologic tumor volumeGBMglioblastoma multiformeFDOPA3,4-dihydroxy-6-[18F]fluoro-L-phenylalanineFETO-(2-[18F]fluoroethyl)-L-tyrosineLATlarge amino acid transporterHGGhigh-grade gliomaLGGlow-grade gliomaMET11C-methioninerCBVrelative CBVTACtime-activity curveTBRtumor-to-background ratioTRCtreatment-related changesTSPOtranslocator proteinWHOWorld Health Organization