RT Journal Article
SR Electronic
T1 Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A7827
A1 R.K. Rigsby
A1 P. Brahmbhatt
A1 A.B. Desai
A1 G. Bathla
A1 B.A. Ebner
A1 V. Gupta
A1 P. Vibhute
A1 A.K. Agarwal
YR 2023
UL http://www.ajnr.org/content/early/2023/03/30/ajnr.A7827.abstract
AB SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.AT/RTatypical teratoid/rhabdoid tumorcIMPACT-NOWConsortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHOGFAPglial fibrillary acidic proteinMAPKmitogen-activated protein kinaseNECnot elsewhere classifiedNOSnot otherwise specifiedPFA and PFBposterior fossa ependymoma groups A and BWHOWorld Health OrganizationWHO CNS5World Health Organization Classification of Tumors of the Central Nervous System, fifth editionIDHisocitrate dehydrogenase