TY - JOUR T1 - Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A7827 AU - R.K. Rigsby AU - P. Brahmbhatt AU - A.B. Desai AU - G. Bathla AU - B.A. Ebner AU - V. Gupta AU - P. Vibhute AU - A.K. Agarwal Y1 - 2023/03/30 UR - http://www.ajnr.org/content/early/2023/03/30/ajnr.A7827.abstract N2 - SUMMARY: In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.AT/RTatypical teratoid/rhabdoid tumorcIMPACT-NOWConsortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHOGFAPglial fibrillary acidic proteinMAPKmitogen-activated protein kinaseNECnot elsewhere classifiedNOSnot otherwise specifiedPFA and PFBposterior fossa ependymoma groups A and BWHOWorld Health OrganizationWHO CNS5World Health Organization Classification of Tumors of the Central Nervous System, fifth editionIDHisocitrate dehydrogenase ER -