RT Journal Article
SR Electronic
T1 Proton MR Spectroscopy of Wernicke Encephalopathy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1803
OP 1806
VO 23
IS 10
A1 Mario Mascalchi
A1 Giacomo Belli
A1 Laura Guerrini
A1 Marco Nistri
A1 Ines Del Seppia
A1 Natale Villari
YR 2002
UL http://www.ajnr.org/content/23/10/1803.abstract
AB Summary: Two patients with acute thiamine deficiency were examined with thalamic single-voxel proton MR spectroscopy. T2-weighted images exhibited increased signal intensity. N-acetylaspartate (NAA)/creatine (Cr) ratios were low without detectable lactate. Owing to substantially decreased choline (Cho) T2, the Cho/Cr ratio was not decreased. After thiamine therapy, the NAA/Cr ratio increased, paralleling clinical improvement and reduction in the areas of signal-intensity changes.