PT - JOURNAL ARTICLE AU - Jun-ichi Takanashi AU - A. James Barkovich AU - Ken-ichi Yamaguchi AU - Yoichi Kohno TI - Influenza-Associated Encephalitis/Encephalopathy with a Reversible Lesion in the Splenium of the Corpus Callosum: A Case Report and Literature Review DP - 2004 May 01 TA - American Journal of Neuroradiology PG - 798--802 VI - 25 IP - 5 4099 - http://www.ajnr.org/content/25/5/798.short 4100 - http://www.ajnr.org/content/25/5/798.full SO - Am. J. Neuroradiol.2004 May 01; 25 AB - Summary: We report the cases of two patients with influenza-associated encephalitis/encephalopathy (IAEE) who presented with mild CNS manifestations and complete recovery within a few days. Initial MR imaging at days 4 and 5 revealed a lesion in the central portion of the splenium of the corpus callosum with a reduced apparent diffusion coefficient (ADC) value, which completely resolved on follow-up studies at day 10. We postulate two possible mechanisms for decreased ADC; namely, intramyelinic edema and an inflammatory infiltrate.