RT Journal Article
SR Electronic
T1 Imaging Features of Primary Intracranial Sarcoma with <em>DICER1</em> Mutation: A Multicenter Case Series
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A8192
A1 Eldaya, Rami W.
A1 Fagan, Richard J.
A1 Dagher, Samir A.
A1 Roy, Angshumoy
A1 Dahyia, Sonika
A1 Fuller, Gregory N.
A1 Wintermark, Max
A1 Parsons, Matthew S.
A1 Huisman, Thierry A.G.M.
YR 2024
UL http://www.ajnr.org/content/early/2024/04/18/ajnr.A8192.abstract
AB Primary intracranial sarcoma, DICER1-mutant, is a rare, recently described entity in the fifth edition of the WHO Classification of CNS Tumors. Given the entity’s rarity and recent description, imaging data on primary intracranial sarcoma, DICER1-mutant, remains scarce. In this multicenter case series, we present detailed multimodality imaging features of primary intracranial sarcoma, DICER1-mutant, with emphasis on the appearance of the entity on MR imaging. In total, 8 patients were included. In all 8 patients, the lesion demonstrated blood products on T1WI. In 7 patients, susceptibility-weighted imagining was obtained and demonstrated blood products. Primary intracranial sarcoma, DICER1-mutant, is a CNS neoplasm that primarily affects pediatric and young adult patients. In the present case series, we explore potential imaging findings that are helpful in suggesting this diagnosis. In younger patients, the presence of a cortical lesion with intralesional blood products on SWI and T1-weighted MR imaging, with or without extra-axial blood products, should prompt the inclusion of this entity in the differential diagnosis.ASLarterial spin-labelingDCEdynamic contrast enhancementSDHsubdural hematoma