RT Journal Article
SR Electronic
T1 Middle Interhemispheric Variant of Holoprosencephaly Associated with Diffuse Polymicrogyria
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 394
OP 397
VO 24
IS 3
A1 Takanashi, Jun-ichi
A1 Barkovich, A. James
A1 Clegg, Nancy J.
A1 Delgado, Mauricio R.
YR 2003
UL http://www.ajnr.org/content/24/3/394.abstract
AB Summary: An 11-month-old boy was discovered to have a cleft palate, club foot, hypospadias, and myoclonic seizures. No in utero exposure to teratogens was identified. Brain MR imaging revealed a middle interhemispheric fusion variant of holoprosencephaly, diffuse polymicrogyria, and a hypoplastic brain stem; this was a distinctly unusual association of findings. We hypothesize that an unknown genetic factor causes disturbances of cleavage of the prosencephalon as well as neuronal migration and organization.