RT Journal Article
SR Electronic
T1 Focal Cortical Dysplasias: MR Imaging, Histopathologic, and Clinical Correlations in Surgically Treated Patients with Epilepsy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 724
OP 733
VO 24
IS 4
A1 Nadia Colombo
A1 Laura Tassi
A1 Carlo Galli
A1 Alberto Citterio
A1 Giorgio Lo Russo
A1 Giuseppe Scialfa
A1 Roberto Spreafico
YR 2003
UL http://www.ajnr.org/content/24/4/724.abstract
AB BACKGROUND AND PURPOSE: Focal cortical dysplasia (FCD) covers a spectrum of conditions in which the neuropathologic and electroclinic presentations and the surgical outcomes vary. The aim of this study was to identify the MR features of histologic subtypes of FCD that would be useful for differential diagnosis.METHODS: We reviewed the MR data of 49 patients treated surgically for intractable partial epilepsy, who received a histologic diagnosis of FCD not associated with other brain abnormalities except hippocampal sclerosis and who were classified by histologic criteria as having architectural dysplasia (28 patients), cytoarchitectural dysplasia (six patients), or Taylor’s FCD (15 patients).RESULTS: From the MR features, it was generally possible to distinguish Taylor’s FCD from architectural or cytoarchitectural dysplasias (non-Taylor’s FCD). Findings suggesting Taylor’s FCD were focal cortical thickening, blurring of the gray-white matter junction, and hyperintensity (on T2-weighted images) of subcortical white matter often tapering toward the ventricle. Focal brain hypoplasia with shrinkage and moderate signal intensity alterations in the white matter core were present in most patients with architectural dysplasia. The lesion was generally extratemporal in Taylor’s FCD and temporal in architectural dysplasia. Ipsilateral hippocampal sclerosis was often present in architectural dysplasia (dual abnormality).CONCLUSIONS: In patients with FCD, Taylor’s FCD and non-Taylor’s FCD can usually be distinguished with MR imaging, although some overlap exists. A provisional MR diagnosis is important for presurgical investigations and surgical planning and may have prognostic implications.