RT Journal Article
SR Electronic
T1 The Value of Apparent Diffusion Coefficient Maps in Early Cerebral Ischemia
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1260
OP 1267
VO 22
IS 7
A1 Patricia M. Desmond
A1 Amanda C. Lovell
A1 Andrew A. Rawlinson
A1 Mark W. Parsons
A1 P. Alan Barber
A1 Qing Yang
A1 Ting Li
A1 David G. Darby
A1 Richard P. Gerraty
A1 Steven M. Davis
A1 Brian M. Tress
YR 2001
UL http://www.ajnr.org/content/22/7/1260.abstract
AB BACKGROUND AND PURPOSE: Prediction of the regions of the ischemic penumbra that are likely to progress to infarction is of great clinical interest. Whether lowered apparent diffusion coefficient (ADC) values were present in the ischemic penumbra of patients presenting with acute ischemic stroke and were specific to regions of the penumbra that proceeded to infarction was investigated.METHODS: Nineteen patients with hemispheric stroke of less than 6 hours' onset and with acute scans showing a perfusion lesion greater than a diffusion lesion (ischemic penumbra) were studied. Scans also were performed subacutely (days 3 to 5) and at outcome (day 90). The outcome scan was used to identify regions of the penumbra that proceeded to infarction.RESULTS: The ADC ratios were significantly reduced (P < .00001) in regions of the penumbra that progressed to infarction on the outcome scan compared with those that remained normal. In regions that showed transition to infarction, the mean ADC ratios were typically 0.75 to 0.90.CONCLUSION: Intermediate ADC values are present in the ischemic penumbra and are indicative of tissue at risk of infarction.