PT  - JOURNAL ARTICLE
AU  - P. Schmidt
AU  - J. Böttcher
AU  - A. Ragoschke-Schumm
AU  - H.J. Mentzel
AU  - G. Wolf
AU  - U.A. Müller
AU  - W.A. Kaiser
AU  - T.E. Mayer
AU  - A. Saemann
TI  - Diffusion-Weighted Imaging of Hyperacute Cerebral Hypoglycemia
AID  - 10.3174/ajnr.A2464
DP  - 2011 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1321--1327
VI  - 32
IP  - 7
4099  - http://www.ajnr.org/content/32/7/1321.short
4100  - http://www.ajnr.org/content/32/7/1321.full
SO  - Am. J. Neuroradiol.2011 Aug 01; 32
AB  - BACKGROUND AND PURPOSE: Cerebral hypoglycemia can result in reversible metabolic brain insults and can be associated with impaired diffusion disturbances. Our aim was to evaluate possible changes in DWI of the human brain during hyperacute short-term severe hypoglycemia. MATERIALS AND METHODS: Ten individuals scheduled for a clinical IST were examined with DWI while the test was performed. Venous blood glucose was continuously measured, and sequential DWI sequences were performed without interruption. Hypoglycemia was terminated with intravenous glucose administration when glucose levels were at ≤2.0 mmol/L. RESULTS: Blood glucose levels were lowered to a mean nadir of 1.75 ± 0.38 mmol/L. No alterations of cerebral diffusion could be observed in any individuals on DWI. CONCLUSIONS: Hyperacute short-term severe hypoglycemia does not induce visible changes in DWI of the human brain. AagitationADCapparent diffusion coefficientBSblurred speechDdrowsinessDAdysaesthesiaDPdyspneaDWIdiffusion-weighted imagingEEGelectroencephalographyFCfeeling coldFGfatigueFLAIRfluid-attenuated inversion recoveryHhungerISTinsulin stress testIVimpaired visionLCloss of consciousnessLMCloss of mental concentrationNnausean.a.not applicableSsweatingTtremorTHthirstVvertigo