RT Journal Article
SR Electronic
T1 Prolonged Venous Transit on Perfusion Imaging Is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A8611
A1 Koneru, Manisha
A1 Mei, Janet Y.
A1 Lakhani, Dhairya A.
A1 Salim, Hamza A.
A1 Shahriari, Mona
A1 Dmytriw, Adam A.
A1 Guenego, Adrien
A1 Heit, Jeremy J.
A1 Albers, Gregory W.
A1 Wolman, Dylan
A1 Faizy, Tobias D.
A1 Pulli, Benjamin
A1 Vagal, Vaibhav
A1 Sriwastwa, Aakanksha
A1 Aziz, Yasmin
A1 Xu, Risheng
A1 Lu, Hanzhang
A1 Urrutia, Victor C.
A1 Marsh, Elisabeth B.
A1 Leigh, Richard
A1 Bahouth, Mona
A1 Llinas, Rafael H.
A1 Nael, Kambiz
A1 Hillis, Argye E.
A1 Yedavalli, Vivek S.
YR 2025
UL http://www.ajnr.org/content/early/2025/04/24/ajnr.A8611.abstract
AB BACKGROUND AND PURPOSE: Prolonged venous transit (PVT+) is a marker of venous outflow; it is defined as the presence or absence of time-to-maximum ≥ 10 seconds timing in either the superior sagittal sinus or torcula. This novel perfusion imaging–based metric has been associated with higher odds of mortality and lower odds of functional recovery. This study aims to assess the relationship between PVT on admission perfusion imaging and length of hospital stay in large vessel occlusion strokes successfully reperfused with mechanical thrombectomy.MATERIALS AND METHODS: Patients with acute ischemic stroke with large vessel occlusions in the anterior circulation successfully treated with thrombectomy between January 2017 and September 2022 were retrospectively reviewed. The primary outcome was length of stay in the hospital due to the acute stroke event. Univariable and forward stepwise multivariable linear regressions were performed for the primary outcome.RESULTS: Of 109 patients meeting inclusion, median age was 71 (interquartile range [IQR] 62–80) years. Median hospital length of stay was significantly greater in PVT+ patients (9 [IQR 6–18] days) compared with PVT- patients (6 [IQR 4–12] days, P = .03). In multivariable regression, PVT+ was significantly associated with length of stay, and PVT+ was associated with approximately 2 additional days of hospital stay compared with PVT- (P = .03).CONCLUSIONS: In successfully reperfused large vessel occlusion strokes, PVT+ was associated with an additional 2 days of hospital stay on average compared with PVT- patients, when adjusting for other clinical covariables. This simple, novel imaging metric is robust in correlating with a range of short- and long-term clinical outcomes.AIS-LVOlarge vessel occlusion acute ischemic strokeIQRinterquartile rangePVTprolonged venous transitrCBFrelative cerebral blood flowSSSsuperior sagittal sinusTmaxtime-to-maximumVIFvariance inflation factorVOvenous outflow