RT Journal Article
SR Electronic
T1 Apparent Diffusion Coefficient with Higher b-Value Correlates Better with Viable Cell Count Quantified from the Cavity of Brain Abscess
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2120
OP 2125
DO 10.3174/ajnr.A2674
VO 32
IS 11
A1 V. Tomar
A1 A. Yadav
A1 R.K.S. Rathore
A1 S. Verma
A1 R. Awasthi
A1 V. Bharadwaj
A1 B.K. Ojha
A1 K.N. Prasad
A1 R.K. Gupta
YR 2011
UL http://www.ajnr.org/content/32/11/2120.abstract
AB BACKGROUND AND PURPOSE: DWI by using higher b-values provides tissue diffusivity with less T2 shinethrough effect. VCD in the abscess cavity correlates with ADC values. The purpose of this study was to investigate which b-value−derived ADC correlates better with VCD. MATERIALS AND METHODS: Thirty patients with brain abscess underwent conventional MR imaging and DWI with b = 1000, 2000, and 3000 s/mm2 on a 3T MR imaging scanner. ADC values were quantified by placing regions of interest inside the abscess cavity in all sections where the lesion was apparent on coregistered ADC maps derived from different b-values. VCD was measured on pus aspirated. RESULTS: An increase in b-value was associated with a decrease in ADC values in normal parenchyma as well as in the abscess cavity. The most significant negative correlation of VCD was observed with b = 3000 s/mm2 (r = −0.98, P = .01). CONCLUSIONS: VCD in the abscess cavity can be best assessed at b = 3000 s/mm2 secondary to the reduction in the T2 shinethrough effect. DWI with b = 3000 s/mm2 is of promising value in the assessment of the therapeutic response of brain abscess. ADCapparent diffusion coefficientCNWMcontralateral normal white matterDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryFWMfrontal white matterGMgray mattersppspeciesVCDviable cell densityWMwhite matter