RT Journal Article
SR Electronic
T1 Gender Differences in Language and Motor-Related Fibers in a Population of Healthy Preterm Neonates at Term-Equivalent Age: A Diffusion Tensor and Probabilistic Tractography Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2011
OP 2016
DO 10.3174/ajnr.A2690
VO 32
IS 11
A1 Liu, Y.
A1 Metens, T.
A1 Absil, J.
A1 De Maertelaer, V.
A1 Balériaux, D.
A1 David, P.
A1 Denolin, V.
A1 Van Overmeire, B.
A1 Avni, F.
A1 Van Bogaert, P.
A1 Aeby, A.
YR 2011
UL http://www.ajnr.org/content/32/11/2011.abstract
AB BACKGROUND AND PURPOSE: Sex differences in white matter structure are controversial. In this MR imaging study, we aimed to investigate possible sex differences in language and motor-related tracts in healthy preterm neonates by using DTI and probabilistic tractography. MATERIALS AND METHODS: Thirty-eight preterm neonates (19 boys and 19 girls, age-matched), healthy at term-equivalent age and at 12 months were included. TBV was measured individually. Probabilistic tractography provided tract volumes, relative tract volumes (volume normalized to TBV), FA, MD, and λ⊥ in the SLF, in the TRs, and in the CSTs. Data were compared by using independent t tests, and Bonferroni corrections were performed to adjust for multiple comparisons. RESULTS: We showed that healthy preterm boys had larger TBV than girls. However, girls had statistically significantly larger relative tract volumes than boys bilaterally in the parieto-temporal SLF, and in the left CST. Moreover, in the left parieto-temporal SLF, a trend toward lower MD and λ⊥ was observed in females. CONCLUSIONS: Structural sex differences were found in preterm neonates at term-equivalent age in both sides of the parieto-temporal SLF and in the left CST. Further studies are necessary to investigate whether these structural differences are related to later sex differences in language skills and handedness or to the effect of prematurity. ATRanterior thalamic radiationCSTcorticospinal tractDTTdiffusion tensor tractographyFAfractional anisotropyGAgestational ageMDmean diffusivityPTRposterior thalamic radiationSENSEsensitivity encodingSLFsuperior longitudinal fasciculusSTRsuperior thalamic radiationTBVtotal brain volumeTRthalamic radiationλ//longitudinal diffusivityλ⊥transverse diffusivity