PT  - JOURNAL ARTICLE
AU  - W.-W. Lee
AU  - J.-S. Kim
AU  - K.R. Son
AU  - H.-M. Kwon
TI  - Atypical Diffusion-Restricted Lesion in 5-Fluorouracil Encephalopathy
AID  - 10.3174/ajnr.A2781
DP  - 2012 Aug 01
TA  - American Journal of Neuroradiology
PG  - E102--E103
VI  - 33
IP  - 7
4099  - http://www.ajnr.org/content/33/7/E102.short
4100  - http://www.ajnr.org/content/33/7/E102.full
SO  - Am. J. Neuroradiol.2012 Aug 01; 33
AB  - SUMMARY: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging. BUNblood urea nitrogenCRFchronic renal failureDPDdihydropyrimidine dehydrogenase5-FU5-fluorouracilPT/INRprothrombin time/international normalized ratio