TY - JOUR T1 - Prediction of Carotid Plaque Characteristics Using Non-Gated MR Imaging: Correlation with Endarterectomy Specimens JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 191 LP - 197 DO - 10.3174/ajnr.A3249 VL - 34 IS - 1 AU - S. Narumi AU - M. Sasaki AU - H. Ohba AU - K. Ogasawara AU - M. Kobayashi AU - J. Hitomi AU - K. Mori AU - K. Ohura AU - M. Yamaguchi AU - K. Kudo AU - Y. Terayama Y1 - 2013/01/01 UR - http://www.ajnr.org/content/34/1/191.abstract N2 - BACKGROUND AND PURPOSE: Electrocardiographic gating, commonly used in MR carotid plaque imaging, can negatively affect intraplaque contrast if the TR is inappropriate. The present study aimed to determine whether a non-gated technique with appropriate TRs can accurately evaluate intraplaque characteristics in specimens excised by CEA. MATERIALS AND METHODS: We prospectively examined 40 consecutive patients who underwent CEA (59–82 years of age) by using a 1.5T scanner. Axial T1WI with a TR of 500 ms and PDWI and T2WI with a TR of 3000 ms with a self-navigated rotating-blade scan instead of cardiac gating were obtained. Signal intensities of the plaque and adjacent muscle were measured, and the CR on T1WI, PDWI, and T2WI as well as the gray-scale median on US were correlated with the pathologic findings of the CEA specimens. RESULTS: On T1WI, the CRs of the carotid plaques differed significantly among groups in which the main components were histologically confirmed as fibrous tissue, lipid/necrosis, and hemorrhage (0.54–1.17, 1.16–1.53, and 1.40–2.29, respectively). The sensitivity and specificity for discriminating lipid/necrosis/hemorrhage from fibrous tissue were 96% and 100%, respectively. On T2WI, the CRs of plaques with lipid/necrosis were significantly higher than those of other groups, but the CRs on PDWI and the gray-scale median on US were not significantly different among the groups. CONCLUSIONS: Non-gated MR plaque imaging, particularly T1WI, can readily predict the intraplaque main components of the carotid artery with high sensitivity and specificity. CEAcarotid endarterectomyCRcontrast ratioECGelectrocardiographMPRAGEmagnetization-prepared rapid acquisition of gradient echoPDWIproton-density–weighted imagingUSultrasonography ER -