RT Journal Article
SR Electronic
T1 Do Early MRI Signals Predict Lesion Size in a Neonatal Stroke Rat Model?
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP E73
OP E76
DO 10.3174/ajnr.A3069
VO 34
IS 7
A1 S. Fau
A1 C. Po
A1 C. Goyenvalle
A1 P. Meric
A1 C. Charriaut-Marlangue
YR 2013
UL http://www.ajnr.org/content/34/7/E73.abstract
AB SUMMARY: In this study, we compared lesion size by using VADC and VT2 at 0, 2, 5, 24, and 48 hours and histologic lesions at 48 hours in a P7 rat stroke model. The best correlation between VHISTO and VADC was at H0, and between VHISTO and VT2, at H2-H5. Early MR imaging signals allowed excluding “no-lesion” and “no-reflow” animals to help standardize this neonatal stroke model and predict lesion size. H0, H2, H5, H24, and H4815 minutes and 2, 5, 24, and 48 hours after reperfusion, respectivelyP77-day-oldRARErapid acquisition relaxation excitementVADCvolume of lesion on ADC mapsVHISTOvolume of lesion on histologic sectionsVT2volume of lesion on T2 maps