TY - JOUR T1 - In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 2407 LP - 2409 DO - 10.3174/ajnr.A4920 VL - 37 IS - 12 AU - I. Park AU - S.J. Nelson AU - J.F. Talbott Y1 - 2016/12/01 UR - http://www.ajnr.org/content/37/12/2407.abstract N2 - SUMMARY: This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with 13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.MRSIMR spectroscopic imaging ER -