PT  - JOURNAL ARTICLE
AU  - Park, I.
AU  - Nelson, S.J.
AU  - Talbott, J.F.
TI  - In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging
AID  - 10.3174/ajnr.A4920
DP  - 2016 Dec 01
TA  - American Journal of Neuroradiology
PG  - 2407--2409
VI  - 37
IP  - 12
4099  - http://www.ajnr.org/content/37/12/2407.short
4100  - http://www.ajnr.org/content/37/12/2407.full
SO  - Am. J. Neuroradiol.2016 Dec 01; 37
AB  - SUMMARY: This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with 13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.MRSIMR spectroscopic imaging