RT Journal Article
SR Electronic
T1 In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2407
OP 2409
DO 10.3174/ajnr.A4920
VO 37
IS 12
A1 I. Park
A1 S.J. Nelson
A1 J.F. Talbott
YR 2016
UL http://www.ajnr.org/content/37/12/2407.abstract
AB SUMMARY: This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with 13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.MRSIMR spectroscopic imaging