PT  - JOURNAL ARTICLE
AU  - C. Anastasopoulos
AU  - M. Reisert
AU  - V.G. Kiselev
AU  - T. Nguyen-Thanh
AU  - A. Schulze-Bonhage
AU  - J. Zentner
AU  - I. Mader
TI  - Local and Global Fiber Tractography in Patients with Epilepsy
AID  - 10.3174/ajnr.A3752
DP  - 2014 Feb 01
TA  - American Journal of Neuroradiology
PG  - 291--296
VI  - 35
IP  - 2
4099  - http://www.ajnr.org/content/35/2/291.short
4100  - http://www.ajnr.org/content/35/2/291.full
SO  - Am. J. Neuroradiol.2014 Feb 01; 35
AB  - BACKGROUND AND PURPOSE: Fiber tractography is increasingly used in the preoperative evaluation of endangered fiber bundles. From a clinical point of view, an accurate and methodologically transparent procedure is desired. Our aim was to evaluate the recently described global tracking algorithm compared with other established methods, such as deterministic and probabilistic tractography. MATERIALS AND METHODS: Twenty patients, candidates for excision of epileptogenic lesions, were subjected to higher-angular resolution diffusion imaging–based fiber tractography. Seed points were created without manual bias, predominantly by FreeSurfer and voxel-based atlases. We focused on 2 important fiber bundles, namely the descending motor pathways and the optic radiation. Postoperatively, the accuracy of the predicted fiber route was controlled by structural MR imaging and by inflicted functional deficits. RESULTS: Among the 3 evaluated methods, global tracking was the only method capable of reconstructing the full extent of the descending motor pathways, including corticobulbar fibers from the area of face representation. Still, probabilistic tractography depicted the optic radiation better, especially the Meyer loop. The deterministic algorithm performed less adequately. CONCLUSIONS: The probabilistic method seems to be the best balance between computational time and effectiveness and seems to be the best choice in most cases, particularly for the optic radiation. If, however, a detailed depiction of the fiber anatomy is intended and tract crossings are implicated, then the computationally time-consuming global tracking should be preferred. DMPdescending motor pathwaysFAfractional anisotropyFACTFiber Assignment by Continuous TractographyORoptic radiationSLFsuperior longitudinal fascicle