TY - JOUR T1 - Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 395 LP - 401 DO - 10.3174/ajnr.A3670 VL - 35 IS - 2 AU - K.W. Yeom AU - L.A. Mitchell AU - R.M. Lober AU - P.D. Barnes AU - H. Vogel AU - P.G. Fisher AU - M.S. Edwards Y1 - 2014/02/01 UR - http://www.ajnr.org/content/35/2/395.abstract N2 - BACKGROUND AND PURPOSE: Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic types of pediatric brain tumors and evaluate the role of arterial spin-labeling in the prediction of tumor grade. MATERIALS AND METHODS: Arterial spin-labeling perfusion of 54 children (mean age, 7.5 years; 33 boys and 21 girls) with treatment-naive brain tumors was retrospectively evaluated. The 3D pseudocontinuous spin-echo arterial spin-labeling technique was acquired at 3T MR imaging. Maximal relative tumor blood flow was obtained by use of the ROI method and was compared with tumor histologic features and grade. RESULTS: Tumors consisted of astrocytic (20), embryonal (11), ependymal (3), mixed neuronal-glial (8), choroid plexus (5), craniopharyngioma (4), and other pathologic types (3). The maximal relative tumor blood flow of high-grade tumors (grades III and IV) was significantly higher than that of low-grade tumors (grades I and II) (P < .001). There was a wider relative tumor blood flow range among high-grade tumors (2.14 ± 1.78) compared with low-grade tumors (0.60 ± 0.29) (P < .001). Across the cohort, relative tumor blood flow did not distinguish individual histology; however, among posterior fossa tumors, relative tumor blood flow was significantly higher for medulloblastoma compared with pilocytic astrocytoma (P = .014). CONCLUSIONS: Characteristic arterial spin-labeling perfusion patterns were seen among diverse pathologic types of brain tumors in children. Arterial spin-labeling perfusion can be used to distinguish high-grade and low-grade tumors. ASLarterial spin-labelingDIPGdiffuse intrinsic pontine gliomaDNTdysembryoplastic tumorOPGoptic pathway gliomarTBFrelative tumor blood flowWHOWorld Health Organization ER -