PT  - JOURNAL ARTICLE
AU  - Lee, Benjamin C. P.
AU  - Brock, John M.
AU  - Fan, Teresa
AU  - Seibert, Anthony
AU  - Moonen, Chrit
AU  - Kissel, Phillip
AU  - Chehrazi, Bahram
AU  - Bradbury, E. Morton
TI  - <sup>31</sup>P Spectroscopy in Thrombolytic Treatment of Experimental Cerebral Infarct
DP  - 1989 Jan 01
TA  - American Journal of Neuroradiology
PG  - 47--52
VI  - 10
IP  - 1
4099  - http://www.ajnr.org/content/10/1/47.short
4100  - http://www.ajnr.org/content/10/1/47.full
SO  - Am. J. Neuroradiol.1989 Jan 01; 10
AB  - Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 31P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.