RT Journal Article
SR Electronic
T1 <sup>31</sup>P Spectroscopy in Thrombolytic Treatment of Experimental Cerebral Infarct
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 47
OP 52
VO 10
IS 1
A1 Lee, Benjamin C. P.
A1 Brock, John M.
A1 Fan, Teresa
A1 Seibert, Anthony
A1 Moonen, Chrit
A1 Kissel, Phillip
A1 Chehrazi, Bahram
A1 Bradbury, E. Morton
YR 1989
UL http://www.ajnr.org/content/10/1/47.abstract
AB Ischemic changes produced by autogenous clot embolization of intracranial arteries were monitored by continuous surface-coil 31P spectroscopy in 12 rabbits: six were used as controls and six were treated intravenously with tissue-type plasminogen activator. The animals were sacrificed and the brains were fixed with intravital stains. The results indicate that spectral changes are reversible only when thrombolysis therapy is started within 30 min after ischemic changes are detected. The improvement of the 31P spectrum correlated with postmortem changes.