TY - JOUR T1 - A Prognostic Model Based on Preoperative MRI Predicts Overall Survival in Patients with Diffuse Gliomas JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1096 LP - 1102 DO - 10.3174/ajnr.A3837 VL - 35 IS - 6 AU - A. Hilario AU - J.M. Sepulveda AU - A. Perez-Nuñez AU - E. Salvador AU - J.M. Millan AU - A. Hernandez-Lain AU - V. Rodriguez-Gonzalez AU - A. Lagares AU - A. Ramos Y1 - 2014/06/01 UR - http://www.ajnr.org/content/35/6/1096.abstract N2 - BACKGROUND AND PURPOSE: Diffuse gliomas are classified as grades II–IV on the basis of histologic features, with prognosis determined mainly by clinical factors and histologic grade supported by molecular markers. Our aim was to evaluate, in patients with diffuse gliomas, the relationship of relative CBV and ADC values to overall survival. In addition, we also propose a prognostic model based on preoperative MR imaging findings that predicts survival independent of histopathology. MATERIALS AND METHODS: We conducted a retrospective analysis of the preoperative diffusion and perfusion MR imaging in 126 histologically confirmed diffuse gliomas. Median relative CBV and ADC values were selected for quantitative analysis. Survival univariate analysis was made by constructing survival curves by using the Kaplan-Meier method and comparing subgroups by log-rank probability tests. A Cox regression model was made for multivariate analysis. RESULTS: The study included 126 diffuse gliomas (median follow-up of 14.5 months). ADC and relative CBV values had a significant influence on overall survival. Median overall survival for patients with ADC < 0.799 × 10−3 mm2/s was <1 year. Multivariate analysis revealed that patient age, relative CBV, and ADC values were associated with survival independent of pathology. The preoperative model provides greater ability to predict survival than that obtained by histologic grade alone. CONCLUSIONS: ADC values had a better correlation with overall survival than relative CBV values. A preoperative prognostic model based on patient age, relative CBV, and ADC values predicted overall survival of patients with diffuse gliomas independent of pathology. This preoperative model provides a more accurate predictor of survival than histologic grade alone. rCBVrelative cerebral blood volume ER -