PT  - JOURNAL ARTICLE
AU  - K. Ishii
TI  - PET Approaches for Diagnosis of Dementia
AID  - 10.3174/ajnr.A3695
DP  - 2014 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2030--2038
VI  - 35
IP  - 11
4099  - http://www.ajnr.org/content/35/11/2030.short
4100  - http://www.ajnr.org/content/35/11/2030.full
SO  - Am. J. Neuroradiol.2014 Nov 01; 35
AB  - SUMMARY: There is increasing use of neuroimaging modalities, including PET, for diagnosing dementia. For example, FDG-PET demonstrates hypometabolic regions in the posterior cingulate gyri, precuneus, and parietotemporal association cortices, while amyloid PET indicates amyloid deposition in Alzheimer disease and mild cognitive impairment due to Alzheimer disease. Furthermore, the use of combination PET with structural MR imaging can improve the diagnostic accuracy of dementia. In other neurodegenerative dementias, each disease exhibits a specific metabolic reduction pattern. In dementia with Lewy bodies, occipital glucose metabolism is decreased, while in frontotemporal dementia, frontal and anterior temporal metabolism is predominantly decreased. These FDG-PET findings and positive or negative amyloid deposits are important biomarkers for various neurodegenerative dementias. Aβamyloid β peptideADAlzheimer diseaseAPOEapolipoprotein ECBDcorticobasal degenerationDLBdementia with Lewy bodiesFTDfrontotemporal dementiaMCImild cognitive impairmentPDParkinson diseasePiBPittsburgh compound-BPSPprogressive supranuclear palsyVBMvoxel-based morphometry