RT Journal Article
SR Electronic
T1 Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: Proposal of an Evidence-Based Combined Clinical and Imaging Reference Standard
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2209
OP 2214
DO 10.3174/ajnr.A3782
VO 35
IS 12
A1 P.C. Sanelli
A1 S. Kishore
A1 A. Gupta
A1 H. Mangat
A1 A. Rosengart
A1 H. Kamel
A1 A. Segal
YR 2014
UL http://www.ajnr.org/content/35/12/2209.abstract
AB SUMMARY: Aneurysmal subarachnoid hemorrhage is associated with high morbidity and mortality, with delayed neurologic deficits from delayed cerebral ischemia contributing to a large portion of the adverse outcomes in this patient population. There is currently no consensus reference standard for establishing the diagnosis of delayed cerebral ischemia either in the research or clinical settings, ultimately limiting strategies for preventing delayed infarction and permanent neurologic deficits. There are currently both clinical and imaging-based criteria for the diagnosis of delayed neurologic deficits and vasospasm, respectively, however, neither clinical nor angiographic assessment alone has been shown to identify patients who develop adverse outcomes from delayed infarction. Thus, the purpose of this work is to propose a 3-tiered combined imaging and clinical reference standard based on evidence from the literature to standardize the diagnosis of delayed cerebral ischemia, both to allow consistency across research studies and to ultimately improve outcomes in the clinical setting. aSAHaneurysmal subarachnoid hemorrhageDCIdelayed cerebral ischemiaMRPMR perfusion