TY - JOUR T1 - Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1859 LP - 1865 DO - 10.3174/ajnr.A4378 VL - 36 IS - 10 AU - M.E. Adin AU - L. Kleinberg AU - D. Vaidya AU - E. Zan AU - S. Mirbagheri AU - D.M. Yousem Y1 - 2015/10/01 UR - http://www.ajnr.org/content/36/10/1859.abstract N2 - BACKGROUND AND PURPOSE: A hyperintense appearance of the dentate nucleus on T1-weighted MR images has been related to various clinical conditions, but the etiology remains indeterminate. We aimed to investigate the possible associations between a hyperintense appearance of the dentate nucleus on T1-weighted MR images in patients exposed to radiation and factors including, but not limited to, the cumulative number of contrast-enhanced MR images, amount of gadolinium administration, dosage of ionizing radiation, and patient demographics.MATERIALS AND METHODS: The medical records of 706 consecutive patients who were treated with brain irradiation at The Johns Hopkins Medical Institutions between 1995 and 2010 were blindly reviewed by 2 readers.RESULTS: One hundred eighty-four subjects were included for dentate nuclei analysis. Among the 184 subjects who cumulatively underwent 2677 MR imaging studies following intravenous gadolinium administration, 103 patients had hyperintense dentate nuclei on precontrast T1-weighted MR images. The average number of gadolinium-enhanced MR imaging studies performed in the group with normal dentate nuclei was significantly lower than that of the group with hyperintense dentate nuclei. The average follow-up time was 62.5 months. No significant difference was observed between hyperintense and normal dentate nuclei groups in terms of exposed radiation dose, serum creatinine and calcium/phosphate levels, patient demographics, history of chemotherapy, and strength of the scanner. No dentate nuclei abnormalities were found on the corresponding CT scans of patients with hyperintense dentate nuclei (n = 44). No dentate nuclei abnormalities were found in 53 healthy volunteers.CONCLUSIONS: Repeat performance of gadolinium-enhanced studies likely contributes to a long-standing hyperintense appearance of dentate nuclei on precontrast T1-weighted-MR images.CEMRIcontrast-enhanced MRIDNdentate nucleusHDNhyperintense appearance of the dentate nucleusNDNnormal dentate nucleusMFSmagnetic field strength of the scannerp 2525th percentilep7575th percentileRDradiation doseRTradiation therapy ER -