TY - JOUR T1 - High-Resolution DCE-MRI of the Pituitary Gland Using Radial <em>k</em>-Space Acquisition with Compressed Sensing Reconstruction JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1444 LP - 1449 DO - 10.3174/ajnr.A4324 VL - 36 IS - 8 AU - M.C. Rossi Espagnet AU - L. Bangiyev AU - M. Haber AU - K.T. Block AU - J. Babb AU - V. Ruggiero AU - F. Boada AU - O. Gonen AU - G.M. Fatterpekar Y1 - 2015/08/01 UR - http://www.ajnr.org/content/36/8/1444.abstract N2 - BACKGROUND AND PURPOSE: The pituitary gland is located outside of the blood-brain barrier. Dynamic T1 weighted contrast enhanced sequence is considered to be the gold standard to evaluate this region. However, it does not allow assessment of intrinsic permeability properties of the gland. Our aim was to demonstrate the utility of radial volumetric interpolated brain examination with the golden-angle radial sparse parallel technique to evaluate permeability characteristics of the individual components (anterior and posterior gland and the median eminence) of the pituitary gland and areas of differential enhancement and to optimize the study acquisition time.MATERIALS AND METHODS: A retrospective study was performed in 52 patients (group 1, 25 patients with normal pituitary glands; and group 2, 27 patients with a known diagnosis of microadenoma). Radial volumetric interpolated brain examination sequences with golden-angle radial sparse parallel technique were evaluated with an ROI-based method to obtain signal-time curves and permeability measures of individual normal structures within the pituitary gland and areas of differential enhancement. Statistical analyses were performed to assess differences in the permeability parameters of these individual regions and optimize the study acquisition time.RESULTS: Signal-time curves from the posterior pituitary gland and median eminence demonstrated a faster wash-in and time of maximum enhancement with a lower peak of enhancement compared with the anterior pituitary gland (P &lt; .005). Time-optimization analysis demonstrated that 120 seconds is ideal for dynamic pituitary gland evaluation. In the absence of a clinical history, differences in the signal-time curves allow easy distinction between a simple cyst and a microadenoma.CONCLUSIONS: This retrospective study confirms the ability of the golden-angle radial sparse parallel technique to evaluate the permeability characteristics of the pituitary gland and establishes 120 seconds as the ideal acquisition time for dynamic pituitary gland imaging.GRASPgolden-angle radial sparse parallelSTCsignal-time curveVIBEvolumetric interpolated brain examination ER -