RT Journal Article
SR Electronic
T1 Medial Occipital Lobe Hyperperfusion Identified by Arterial Spin-Labeling: A Poor Prognostic Sign in Patients with Hypoxic-Ischemic Encephalopathy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2292
OP 2295
DO 10.3174/ajnr.A4444
VO 36
IS 12
A1 de Havenon, A.
A1 Sultan-Qurraie, A.
A1 Tirschwell, D.
A1 Cohen, W.
A1 Majersik, J.
A1 Andre, J.B.
YR 2015
UL http://www.ajnr.org/content/36/12/2292.abstract
AB SUMMARY: Hypoxic-ischemic encephalopathy carries an uncertain prognosis. We sought to retrospectively assess the prognostic value of arterial spin-labeling MR imaging in 22 adult patients diagnosed with hypoxic-ischemic encephalopathy. Quantitative CBF maps were generated from the M0 map, and arterial spin-labeling data on a per-voxel basis were regionally interrogated via visual inspection and ROI placement. Hyperperfusion was defined as regional increases in CBF of >20% (relative to global CBF) and/or >100 mL/100 g/min. Eleven of 22 patients had prominent bilateral medial occipital lobe hyperperfusion, all of whom died before hospital discharge. One patient who had nondistinct arterial spin-labeling hyperperfusion and restricted diffusion survived. Medial occipital lobe hyperperfusion is a distinctive pattern that merits prospective investigation in a cohort of patients with moderate hypoxic-ischemic encephalopathy to determine its predictive ability in patients with a higher likelihood of survival.ASLarterial spin-labelingHIEhypoxic-ischemic encephalopathyMOLHmedial occipital lobe hyperperfusion