PT  - JOURNAL ARTICLE
AU  - S. Gaddikeri
AU  - R.S. Gaddikeri
AU  - T. Tailor
AU  - Y. Anzai
TI  - Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer: Techniques and Clinical Applications
AID  - 10.3174/ajnr.A4458
DP  - 2016 Apr 01
TA  - American Journal of Neuroradiology
PG  - 588--595
VI  - 37
IP  - 4
4099  - http://www.ajnr.org/content/37/4/588.short
4100  - http://www.ajnr.org/content/37/4/588.full
SO  - Am. J. Neuroradiol.2016 Apr 01; 37
AB  - SUMMARY: In the past decade, dynamic contrast-enhanced MR imaging has had an increasing role in assessing the microvascular characteristics of various tumors, including head and neck cancer. Dynamic contrast-enhanced MR imaging allows noninvasive assessment of permeability and blood flow, both important features of tumor hypoxia, which is a marker for treatment resistance for head and neck cancer. Dynamic contrast-enhanced MR imaging has the potential to identify early locoregional recurrence, differentiate metastatic lymph nodes from normal nodes, and predict tumor response to treatment and treatment monitoring in patients with head and neck cancer. Quantitative analysis is in its early stage and standardization and refinement of technique are essential. In this article, we review the techniques of dynamic contrast-enhanced MR imaging data acquisition, analytic methods, current limitations, and clinical applications in head and neck cancer.AIFarterial input functionDCE–MR imagingdynamic contrast-enhanced MR imagingEESextracellular extravascular spaceGCAgadolinium contrast agentHNChead and neck cancerKeptransfer function from EES to the plasma spaceKtransvolume transfer constantVeextravascular extracellular volume fraction