PT  - JOURNAL ARTICLE
AU  - Armoiry, X.
AU  - Turjman, F.
AU  - Hartmann, D.J.
AU  - Sivan-Hoffmann, R.
AU  - Riva, R.
AU  - Labeyrie, P.E.
AU  - Aulagner, G.
AU  - Gory, B.
TI  - Endovascular Treatment of Intracranial Aneurysms with the WEB Device: A Systematic Review of Clinical Outcomes
AID  - 10.3174/ajnr.A4611
DP  - 2016 May 01
TA  - American Journal of Neuroradiology
PG  - 868--872
VI  - 37
IP  - 5
4099  - http://www.ajnr.org/content/37/5/868.short
4100  - http://www.ajnr.org/content/37/5/868.full
SO  - Am. J. Neuroradiol.2016 May 01; 37
AB  - BACKGROUND AND PURPOSE: Despite the improvement in technology, endovascular treatment of bifurcation intracranial wide-neck aneurysms remains challenging, mainly due to the difficulty of maintaining coils within the aneurysm sac without compromising the patency of bifurcation arteries. The Woven EndoBridge (WEB) device is a recent intrasaccular braided device specifically dedicated to treating such aneurysms with a wide neck by disrupting the flow in the aneurysmal neck and promoting progressive aneurysmal thrombosis.MATERIALS AND METHODS: Using several health data bases, we conducted a systematic review of all published studies of WEB endovascular treatment in intracranial aneurysms from 2010 onward to evaluate its efficacy and safety profile.RESULTS: The literature search identified 6 relevant studies (7 articles) including wide-neck bifurcation aneurysms in ≥80% of cases. Clinical data supporting the efficacy and safety of the WEB are limited to noncomparative cohort studies with large heterogeneity from a methodologic standpoint. The WEB deployment was feasible with a success rate of 93%–100%. Permanent morbidity (mRS of >1 at last follow-up) and mortality were measured at 2.2%–6.7% and 0%–17%, respectively. The adequate occlusion rate (total occlusion or neck remnant) varied between 65% and 85.4% at midterm follow-up (range, 3.3–27.4 months).CONCLUSIONS: Endovascular treatment of bifurcation wide-neck aneurysms with the WEB device is feasible and allows an acceptably adequate aneurysm occlusion rate; however, the rate of neck remnants is not negligible. The WEB device needs further clinical and anatomic evaluation with long-term prospective studies, especially of the risk of WEB compression. Prospective controlled studies should be encouraged.CEConformité EuropéennePRISMAPreferred Reporting Items for Systematic Reviews and Meta-AnalysesWEBWoven EndoBridgeWEB-DLWoven EndoBridge Dual-LayerWEB-SLWoven EndoBridge Single-LayerWEB-SLSWoven EndoBridge Single-Layer Sphere