PT  - JOURNAL ARTICLE
AU  - Zhang, Tian
AU  - Matsumura, Akira
AU  - Yamamoto, Tetsuya
AU  - Yoshida, Fumiyo
AU  - Nose, Tadao
AU  - Shimojo, Nobuhiro
TI  - Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine: A Study of MR Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy in Rat Brain Tumors
DP  - 2002 Jan 01
TA  - American Journal of Neuroradiology
PG  - 15--18
VI  - 23
IP  - 1
4099  - http://www.ajnr.org/content/23/1/15.short
4100  - http://www.ajnr.org/content/23/1/15.full
SO  - Am. J. Neuroradiol.2002 Jan 01; 23
AB  - BACKGROUND AND PURPOSE: After the advent of extracellular contrast media, hepatobiliary-specific gadolinium chelates were developed to improve the diagnostic value of MR imaging of the liver. Gadobenate dimeglumine (Gd-BOPTA) is a new paramagnetic contrast agent with partial biliary excretion that produces prolonged enhancement of liver parenchyma on T1-weighted images. However, whether Gd-BOPTA is useful as a contrast agent in central nervous system disease, particularly in brain tumors, is unclear.METHODS: The behavior of Gd-BOPTA as a brain tumor–selective contrast agent was compared with that of gadopentetate dimeglumine (Gd-DTPA), an MR contrast agent used in central nervous system disease, in a common dose of 0.1 mmol/kg. An MR imaging study of these two contrast agents was performed, and tissue concentrations were measured with inductively coupled plasma atomic emission spectroscopy (ICP-AES).RESULTS: Gd-BOPTA showed better MR imaging enhancement in brain tumors than did Gd-DTPA at every time course until 2 hours after administration and no enhancement in peritumoral tissue and normal brain. Corresponding results with ICP-AES showed significantly greater uptake of Gd-BOPTA in tumor samples than that in peritumoral tissue and normal brain 5 minutes after administration. Gadolinium was retained for a longer time in brain tumors when Gd-BOPTA rather than Gd-DTPA was administered.CONCLUSION: Gd-BOPTA is a useful contrast agent for MR imaging in brain tumors and possibly an effective absorption agent for neutron capture therapy.