TY - JOUR T1 - Reversible Tacrolimus-induced Neurotoxicity Isolated to the Brain Stem JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1251 LP - 1254 VL - 21 IS - 7 AU - Patrick J. Oliverio AU - Lucas Restrepo AU - Sandra A. Mitchell AU - Carlo S. Tornatore AU - Stanley R. Frankel Y1 - 2000/08/01 UR - http://www.ajnr.org/content/21/7/1251.abstract N2 - Summary: Diplopia, nystagmus, visual hallucinations, and internuclear ophthalmoplegia developed in a 30-year-old woman 84 days after she received a matched, unrelated bone marrow transplant for chronic myeloid leukemia. A regimen of tacrolimus had been administered since the transplantation was performed. MR imaging revealed bilaterally symmetric regions of signal abnormality with abnormal contrast enhancement in the brain stem. No supratentorial abnormality was present. Tacrolimus therapy was discontinued, and the symptoms resolved. MR imaging that was performed 10 days after tacrolimus was discontinued showed resolution of the abnormalities. ER -