RT Journal Article SR Electronic T1 Reversible Tacrolimus-induced Neurotoxicity Isolated to the Brain Stem JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1251 OP 1254 VO 21 IS 7 A1 Patrick J. Oliverio A1 Lucas Restrepo A1 Sandra A. Mitchell A1 Carlo S. Tornatore A1 Stanley R. Frankel YR 2000 UL http://www.ajnr.org/content/21/7/1251.abstract AB Summary: Diplopia, nystagmus, visual hallucinations, and internuclear ophthalmoplegia developed in a 30-year-old woman 84 days after she received a matched, unrelated bone marrow transplant for chronic myeloid leukemia. A regimen of tacrolimus had been administered since the transplantation was performed. MR imaging revealed bilaterally symmetric regions of signal abnormality with abnormal contrast enhancement in the brain stem. No supratentorial abnormality was present. Tacrolimus therapy was discontinued, and the symptoms resolved. MR imaging that was performed 10 days after tacrolimus was discontinued showed resolution of the abnormalities.