RT Journal Article
SR Electronic
T1 Apoptosis in Leukoaraiosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 79
OP 82
VO 21
IS 1
A1 William R. Brown
A1 Dixon M. Moody
A1 Clara R. Thore
A1 Venkata R. Challa
YR 2000
UL http://www.ajnr.org/content/21/1/79.abstract
AB Summary: We report a case of leukoaraiosis that was studied for apoptosis. In the neuropil, the number of cells that showed DNA fragmentation was 2.5 times as great in the area of leukoaraiosis as in the adjacent white matter (P = .004) and 25 times as great as in the nearby cortex (P < .001). Our findings suggest that apoptosis, predominantly of oligodendrocytes, is involved in the pathogenesis of leukoaraiosis. Within the area of leukoaraiosis, we also found numerous small veins that were partially occluded by severe collagenous thickening of the vessel walls. This collagenosis may have contributed to or resulted from chronic ischemia in that area.